Manganese-Catalyzed Electrochemical Deconstructive Chlorination of Cycloalkanols via Alkoxy Radicals
Manganese-Catalyzed Electrochemical Deconstructive Chlorination of Cycloalkanols via Alkoxy Radicals
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DOI：
10.26434/chemrxiv.9275441.v1
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发表时间：
2019-08
期刊：
影响因子：
5.2
通讯作者：
Benjamin D W Allen;Mishra Deepak Hareram;Alex C Seastram;T. McBride;T. Wirth;D. Browne;Louis C. Morrill-Loui
中科院分区：
文献类型：
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作者：
Benjamin D W Allen;Mishra Deepak Hareram;Alex C Seastram;T. McBride;T. Wirth;D. Browne;Louis C. Morrill-Loui
研究了锰催化环烷醇的电化学解构氯化反应。这种电化学方法提供了从醇获得烷氧基的途径，并表现出广泛的底物范围，各种环丙醇和环丁醇转化为合成有用的β-和γ-氯化酮（40个实例）。此外，采用再循环流动电化学和连续在线纯化的组合来获得克级的产物。
A manganese-catalyzed electrochemical deconstructive chlorination of cycloalkanols has been developed. This electrochemical method provides access to alkoxy radicals from alcohols and exhibits a broad substrate scope, with various cyclopropanols and cyclobutanols converted into synthetically useful β- and γ-chlorinated ketones (40 examples). Furthermore, the combination of recirculating flow electrochemistry and continuous inline purification was employed to access products on a gram scale.