Associations between SNPs in toll-like receptors and related intracellular signaling molecules and immune responses to measles vaccine: Preliminary results
Associations between SNPs in toll-like receptors and related intracellular signaling molecules and immune responses to measles vaccine: Preliminary results
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DOI：
10.1016/j.vaccine.2008.01.017
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发表时间：
2008-03-25
期刊：
影响因子：
5.5
通讯作者：
Poland, Gregory A.
中科院分区：
文献类型：
--
作者：
Dhiman, Neelam;Ovsyannikova, Inna G.;Poland, Gregory A.
toll样受体（TLRs）是先天性免疫和适应性免疫之间的关键“桥梁”。我们假设可能影响tlr及其相关细胞内信号分子表达/功能的单核苷酸多态性（snp）有助于麻疹疫苗的体液和细胞免疫变化。我们随机选择190名受试者（12-18岁），之前接种过两剂麻疹疫苗，对已知的TLR 2、3、4、5、6、7、8和9的snp及其相关的细胞内信号基因进行了基因分型。tlr2、3、4、5、6、MYD88和MD2基因的特异性snp与麻疹特异性体液和细胞免疫有关。TLR3基因的rs3775291 （Phe412Leu）和rs5743305（启动子区-926 bp）的杂合变异体与低抗体和淋巴细胞增生性反应相关(p
Toll-like receptors (TLRs) represent the critical "bridge" between innate and adaptive immunity to viral pathogens. We hypothesized that single nucleotide potymorphisms (SNPs) that potentially influence the expression/function of TLRs and their associated intracellular signaling molecules contribute to variations in humoral and cellular immunity to measles vaccine. We genotyped 190 randomly selected subjects (12-18 years old), previously vaccinated with two doses of measles, for known SNPs in TLR 2, 3, 4, 5, 6, 7, 8 and 9, and their associated intracellular signaling genes. Specific SNPs in the TLR 2, 3, 4, 5, 6, MYD88 and MD2 genes were associated with measles-specific humoral and cellular immunity. Heterozygous variants for rs3775291 (Phe412Leu) and rs5743305 (-926 bp in promoter region) of the TLR3 gene were associated with low antibody and tymphoprotiferative responses (p