Aging alters the serotonergic modulation of light-induced phase advances in golden hamsters.
Aging alters the serotonergic modulation of light-induced phase advances in golden hamsters.
复制标题
衰老改变了金仓鼠光诱导相位提前的血清素调节。
DOI：
10.1152/ajpregu.1997.272.2.r509
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Zee,PC
中科院分区：
文献类型：
--
作者：
Penev,PD;Turek,FW;Wallen,EP;Zee,PC
Recent findings have raised the possibility that some of the age-related changes in the circadian system and the response of the circadian pacemaker to environmental stimuli may involve central serotonergic mechanisms. The present study compared the effects ofpretreatment with the serotonin agonist 8-hydroxy-2(di-n-propylamino)tetralin (5 mg/kg ip) on the magnitude of light-induced phase advances in young (2-4 mo) and old (18-20 mo) golden hamsters. The ability of this serotonin agonist to attenuate the photic phase resetting of circadian locomotor rhythmicity in young animals was decreased by 46% in old hamsters (P < 0.05). These results suggest that deficits in the mechanisms for serotonergic control of circadian function may interfere with the optimal adaptation of the senescent organism to its temporal environment.
