External validation and clinical evaluation of the International Prognostic Score of Thrombosis for Essential Thrombocythemia (IPSET-thrombosis) in a large cohort of Chinese patients
External validation and clinical evaluation of the International Prognostic Score of Thrombosis for Essential Thrombocythemia (IPSET-thrombosis) in a large cohort of Chinese patients
复制标题
原发性血小板增多症血栓形成国际预后评分（IPSET-血栓形成）在大型中国患者队列中的外部验证和临床评估
DOI：
10.1111/ejh.12275
复制
发表时间：
2014-06-01
影响因子：
3.1
通讯作者：
Yang, Renchi
中科院分区：
文献类型：
--
作者：
Fu, Rongfeng;Xuan, Min;Yang, Renchi
目的原发性血小板增多症（ET）患者的血管并发症是其发病率和死亡率的主要原因。为了更好地预测血栓事件的发生，最近开发了ET血栓形成的国际预后评分（IPSET-血栓形成）。我们在此提出了在一个大型中国患者队列中对该模型的外部验证和分析。方法回顾性分析970例ET患者血栓形成的特点和危险因素，并评估IPSET血栓形成模型的临床意义。结果随访0-360个月，中位49个月。中国ET患者的临床特征与高加索患者相似。与IPSET-血栓形成研究相似，我们的多变量分析显示年龄>60岁（HR=1.949）、既往血栓形成（HR=2.484）、JAK 2 V617 F突变（HR=1.719）和心血管危险因素（HR=1.877）是血栓形成的独立危险因素。我们证实，与传统的风险因素（例如，年龄>= 60岁和既往血栓形成事件）更能预测血栓形成事件（C指数0.714 vs. 0.647）。IPSET血栓形成危险组的分类显示不同的累积无血栓形成生存率（P
Objectives In patients with essential thrombocythemia (ET), vascular complications contribute to both morbidity and mortality. To better predict the occurrence of thrombotic events, an International Prognostic Score of thrombosis for ET (IPSET-thrombosis) was recently developed. We hereby presented an external validation and analysis of this model in a large Cohort of Chinese Patients. Methods We retrospectively evaluated the characteristics and risk factors for thrombosis in 970 Chinese patients with ET and estimated the clinical implications of the IPSET-thrombosis model. Results The median follow-up was 49months (range, 0-360). Chinese ET patients had similar clinical characteristics as Caucasian patients. Similar to the IPSET-thrombosis study, our multivariate analysis revealed age >60 (HR=1.949), previous thrombosis (HR=2.484), JAK2V617F mutation (HR=1.719), and cardiovascular risk factors (HR=1.877) as independent risk factors for thrombosis. We confirmed that the above risk factors in IPSET-thrombosis, when compared with traditional risk factors (e.g., age >= 60 and previous thrombotic events), were more predictive of thrombotic events (C-index 0.714 vs. 0.647). Classification by IPSET-thrombosis risk groups revealed different cumulative thrombosis-free survival (P