Metabolic pathways regulated by p63
Metabolic pathways regulated by p63
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DOI：
10.1016/j.bbrc.2016.10.094
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发表时间：
2017-01-15
影响因子：
3.1
通讯作者：
Melino, Gerry
中科院分区：
文献类型：
--
作者：
Candi, Eleonora;Smirnov, Artem;Melino, Gerry
转录因子 p63 属于 p53 家族，是发育和组织稳态过程中上皮细胞增殖潜力、谱系规范和分化的主要调节因子。在癌症中，p63 的贡献是异构体特异性的，分别对 Delta Np63 和 TAp63 具有致癌和肿瘤抑制作用。最近，p53 和 TAp73 与其他肿瘤抑制基因一样，已成为癌症中能量代谢和代谢重编程的重要调节因子。迄今为止，p63 在控制能量代谢方面的贡献已得到部分研究。鉴于 p53 家族成员之间的广泛相互作用，这些研究对肿瘤细胞的代谢重编程具有潜在的影响。在这里，我们回顾了 p63 异构体 TAp63 和 ANp63 在控制细胞代谢中的作用，重点关注它们的特定代谢靶基因及其生理功能作用背景。 (C) 2016 Elsevier Inc. 保留所有权利。
The transcription factor p63 belongs to the p53-family and is a master regulator of proliferative potential, lineage specification, and differentiation in epithelia during development and tissue homeostasis. In cancer, p63 contribution is isoform-specific, with both oncogenic and tumour suppressive roles attributed, for Delta Np63 and TAp63, respectively. Recently, p53 and TAp73, in line with other tumour suppressor genes, have emerged as important regulators of energy metabolism and metabolic reprogramming in cancer. To date, p63 contributions in controlling energy metabolism have been partially investigated; given the extensive interaction of the p53 family members, these studies have potential implications in tumour cells for metabolic reprogramming. Here, we review the role of p63 isoforms, TAp63 and ANp63, in controlling cell metabolism, focusing on their specific metabolic target genes and their physiological functional context of action. (C) 2016 Elsevier Inc. All rights reserved.