Pre-Morbid Risk Factors for Amyotrophic Lateral Sclerosis: Prospective Cohort Study.
Pre-Morbid Risk Factors for Amyotrophic Lateral Sclerosis: Prospective Cohort Study.
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DOI：
10.2147/clep.s329521
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发表时间：
2021
影响因子：
3.9
通讯作者：
Gale CR
中科院分区：
文献类型：
--
作者：
Batty GD;Gale CR
肌萎缩性侧索硬化症（ALS）是一种高病死率的神经退行性疾病，由于缺乏有效的治疗方法，因此明确需要确定其主要危险因素。英国生物银行是一项前瞻性队列研究，在2006年至2010年期间收集了502,649名年龄在37至73岁之间的参与者的基线数据。通过国家登记处对ALS住院和死亡进行随访。11年的事件监测导致301人住院，279人因ALS死亡。在对选定的混杂因素进行校正后，年龄较大（每10年增加的风险比；95%可信区间：1.92;1.58,2.33）和男性（1.37;1.00,1.87）与ALS住院率升高相关。类似的效果也很明显，当死亡归因于疾病是感兴趣的结果。然而，在剩下的23项社会、生物和行为风险指数中，只有一项表明高个子的人住院的风险增加（每标准差增加：1.31;1.09,1.59）。在目前的大规模研究中，除了已知的关联外，我们没有发现其他风险指标与ALS相关的令人信服的证据。
In the absence of effective treatments for amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder with high case fatality, there is a clear need to identify its primary risk factors. UK Biobank is a prospective cohort study in which baseline data were captured between 2006 and 2010 in 502,649 participants aged 37 to 73 years. Follow-up for ALS hospitalisations and death was made via national registries. Eleven years of event surveillance gave rise to 301 hospitalisations and 279 deaths due to ALS. After adjustment for selected confounding factors, being older (hazard ratio per 10 year increase; 95% confidence interval: 1.92; 1.58, 2.33) and male (1.37; 1.00, 1.87) were associated with elevated rates of hospitalisation for ALS. Similar effects were apparent when death ascribed to the disorder was the outcome of interest. Of the remaining 23 social, biological, and behavioural risk indices, however, there was only a suggestion that taller people experienced an increased risk of hospitalisation (per SD increase: 1.31; 1.09, 1.59). In the present, large-scale study, other than well known associations, we did not find convincing evidence of links with ALS for other risk indices.