Depletion interactions in the protein limit: Effects of polymer density fluctuations
Depletion interactions in the protein limit: Effects of polymer density fluctuations
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DOI：
10.1103/physrevlett.83.4554
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发表时间：
1999-11-29
影响因子：
8.6
通讯作者：
Zukoski, CF
中科院分区：
文献类型：
--
作者：
Kulkarni, AM;Chatterjee, AP;Zukoski, CF
我们报告的第二维里系数的蛋白质溶液，B-2，作为非吸附聚合物的浓度增加的非单调变化的第一个观察。在B-2中观察到的最小值不能从标准耗尽相互作用能模型预测，并且与接近聚合物溶液的较低临界溶解温度密切相关。最小值的位置、深度和分子量依赖性由用于耗尽相互作用的热聚合物参考相互作用模型捕获，其中聚合物网格尺寸是温度的函数。
We report the first observations of nonmonotonic changes in the second virial coefficients of protein solutions, B-2, as the concentration of nonadsorbing polymer is increased. The observed minimum in B-2 cannot be predicted from standard depletion interaction energy models and is closely associated with proximity to the lower critical solution temperature of the polymer solution. The location, depth, and molecular weight dependence of the minima are captured by the thermal polymer reference interaction sire model for depletion interactions, where the polymer mesh size is a function of temperature.