The ATP synthase is involved in generating mitochondrial cristae morphology
The ATP synthase is involved in generating mitochondrial cristae morphology
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DOI：
10.1093/emboj/21.3.221
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发表时间：
2002-02-01
期刊：
影响因子：
11.4
通讯作者：
Velours, J
中科院分区：
文献类型：
--
作者：
Paumard, P;Vaillier, J;Velours, J
线粒体的内膜向内折叠，形成冠状突起。这种折叠允许更多的膜被装入线粒体。本研究中的数据表明，线粒体ATP合成酶的e和g亚基参与了线粒体脊形态的形成。这两个亚基是三磷酸腺苷合成酶的非必需成分，是三磷酸腺苷合成酶的二聚化和寡聚化所必需的。缺乏e或g亚基的酵母细胞的线粒体具有大量的指状突起和洋葱状结构，这与线粒体内膜的不受控制的生物发生和/或折叠相对应。目前的数据表明，线粒体ATP合成酶的二聚化与冠状突起的形态之间存在联系。考虑到酵母酶的寡聚化和线粒体脊超微结构的早期数据，提出了一个ATP合成酶二聚体的组装模型，这表明ATP合成酶二聚体的结合参与了线粒体内膜的生物发生控制。
The inner membrane of the mitochondrion folds inwards, forming the cristae. This folding allows a greater amount of membrane to be packed into the mitochondrion. The data in this study demonstrate that subunits e and g of the mitochondrial ATP synthase are involved in generating mitochondrial cristae morphology. These two subunits are non-essential components of ATP synthase and are required for the dimerization and oligomerization of ATP synthase. Mitochondria of yeast cells deficient in either subunits e or g were found to have numerous digitations and onion-like structures that correspond to an uncontrolled biogenesis and/or folding of the inner mitochondrial membrane. The present data show that there is a link between dimerization of the mitochondrial ATP synthase and cristae morphology. A model is proposed of the assembly of ATP synthase dimers, taking into account the oligomerization of the yeast enzyme and earlier data on the ultrastructure of mitochondrial cristae, which suggests that the association of ATP synthase dimers is involved in the control of the biogenesis of the inner mitochondrial membrane.