Life of Listeria monocytogenes in the host cells' cytosol
Life of Listeria monocytogenes in the host cells' cytosol
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DOI：
10.1016/j.micinf.2007.05.006
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发表时间：
2007-08-01
影响因子：
5.8
通讯作者：
Goebel, Werner
中科院分区：
文献类型：
--
作者：
Joseph, Biju;Goebel, Werner
在过去的几十年里，关于细胞内细菌与其宿主细胞之间相互作用的基本机制已经积累了令人印象深刻的知识。相对而言，很少有人知道这些细菌在其特定的宿主细胞隔室内有效复制所需的代谢要求。功能基因组学的最新发展导致了对代谢方面的更广泛的研究，这对于理解细胞内细菌的发病机制可能是至关重要的。本文综述了L.单核细胞增多症，重点是那些部分，似乎是重要的能力，复制在哺乳动物宿主细胞的胞质溶胶。(C)2007年，Elsevier Masson SAS。All rights reserved.
In the past decades impressive knowledge has been accumulated concerning the basic mechanisms of interactions between intracellular bacteria and their host cells. Comparatively little is known on the metabolic requirements necessary for efficient replication of these bacteria within their specific host cell compartments. Recent developments in functional genomics have led to more extensive studies of the metabolic aspects that may be crucial for understanding the pathogenesis of intracellular bacteria. Here we summarize our present knowledge on the physiology of L. monocytogenes with emphasis on those parts that seem to be important for its ability to replicate in the cytosol of mammalian host cells. (C) 2007 Elsevier Masson SAS. All rights reserved.