Palladium-catalyzed aryl-amidation.: Synthesis of non-racemic N-aryl lactams
Palladium-catalyzed aryl-amidation.: Synthesis of non-racemic N-aryl lactams
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DOI：
10.1016/j.tet.2003.11.008
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发表时间：
2004-01-05
期刊：
影响因子：
2.1
通讯作者：
Lovely, CJ
中科院分区：
文献类型：
--
作者：
Browning, RG;Badarinarayana, V;Lovely, CJ
采用Buchwald/Hartwig芳基胺化法，以一种常见的吡咯烷酮前体和相应的芳基溴为原料，构建了一系列手性、非外消旋的n-芳基吡咯烷酮。通过外消旋化合物的合成和用Pirkle手性溶剂化剂的H-1 NMR比较，证明了交叉偶联后n -芳基内酰胺的立体化学完整性。(C) 2003 Elsevier Ltd.版权所有。
The Buchwald/Hartwig aryl amination method was used to construct a series of chiral, non-racemic N-aryl pyrrolidinones from a common pyrrolidinone precursor and the corresponding aryl bromide. The stereochemical integrity of the N-aryl lactam after cross-coupling was proven by synthesis of the racemic compounds and comparison by H-1 NMR spectroscopy using Pirkle's chiral solvating agent. (C) 2003 Elsevier Ltd. All rights reserved.