NEAR-INFRARED SPECTROSCOPY (NIRS) - A NEW TOOL TO STUDY HEMODYNAMIC-CHANGES DURING ACTIVATION OF BRAIN-FUNCTION IN HUMAN ADULTS
NEAR-INFRARED SPECTROSCOPY (NIRS) - A NEW TOOL TO STUDY HEMODYNAMIC-CHANGES DURING ACTIVATION OF BRAIN-FUNCTION IN HUMAN ADULTS
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DOI：
10.1016/0304-3940(93)90181-j
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发表时间：
1993-05-14
影响因子：
2.5
通讯作者：
DIRNAGL, U
中科院分区：
文献类型：
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作者：
VILLRINGER, A;PLANCK, J;DIRNAGL, U
在健康成人中，使用近红外光谱（NIRS）评估大脑激活过程中含氧血红蛋白（[HbO2]）和脱氧血红蛋白（[HbR]）的浓度。在执行认知任务时，在额叶皮层（n=10）进行测量，在视觉刺激（闪光灯照射，图片观察）时在枕叶皮层（n=6）进行测量。在大脑激活过程中，典型的发现是[HbO2]增加，[HbR]减少。我们证明这些发现不是由于皮肤血流量的改变。近红外光谱是一种简单的床边技术，用于评估伴随大脑激活的血流动力学改变。
In healthy human adults, cerebral concentrations of oxygenated hemoglobin ([HbO2]) and deoxygenated hemoglobin ([HbR]) were assessed during brain activation using near infrared spectroscopy (NIRS). Measurements were made either in the frontal cortex (n=10) during performance of cognitive tasks or in the occipital cortex (n=6) during visual stimulation (flash-light exposure, picture observation). The typical findings during brain activation were an increase in [HbO2] and a decrease in [HbR]. We demonstrate that these findings are not due to alterations in skin blood flow. NIRS is a simple bedside technique for the assessment of hemodynamic alterations accompanying brain activation.