Validity of Medication Adherence Self-Reports in Adults With Type 2 Diabetes
Validity of Medication Adherence Self-Reports in Adults With Type 2 Diabetes
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DOI：
10.2337/dc12-0410
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发表时间：
2013-04-01
期刊：
影响因子：
16.2
通讯作者：
Safren, Steven A.
中科院分区：
文献类型：
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作者：
Gonzalez, Jeffrey S.;Schneider, Havah E.;Safren, Steven A.
研究设计和方法-2型糖尿病成人患者，口服药物治疗，完成了一套药物依从性自我报告，不同的反应量表和时间框架，管理抑郁症的结构化临床访谈，并提供了HbA（1c）的血液样本，作为干预研究筛查的一部分。HbA（1c）≥ 7.0%和临床显著抑郁的参与者的子样本接受了药物事件监测系统（MEMS）瓶盖以记录依从性。分析检查了依从性指标与HbA（1c）之间的关系，并在子样本中，MEMS。中度线性回归评估抑郁严重程度是否改变了与HbA（1c）的关系。研究参与者（n = 170，57%男性，81%白色，平均HbA（1c）8.3% [SD，1.7]）的依从性自我报告与较低的HbA（1c）显著相关（r = -0.18至-0.28; P < 0.03）。在子样本（n = 88）中，所有自我报告均显著（r = 0.35至0.55; P
OBJECTIVE-To assess the validity of self-report measures of diabetes medication adherence and evaluate the effect of depression on the validity of these reports.RESEARCH DESIGN AND METHODS-Adults with type 2 diabetes, treated with oral medications, completed a set of medication adherence self-reports that varied response scales and time frames, were administered structured clinical interviews for depression, and provided blood samples for HbA(1c) as part of a screening for an intervention study. A subsample of participants with HbA(1c) >= 7.0% and clinically significant depression received Medication Event Monitoring System (MEMS) bottle caps to record adherence. Analyses examined relationships between adherence measures and HbA(1c) and, in the subsample, MEMS. Moderated linear regression evaluated whether depression severity modified relationships with HbA(1c).RESULTS-Participant (n = 170, 57% men, 81% white, mean HbA(1c) 8.3% [SD, 1.7]) adherence self-reports were significantly (r = -0.18 to -0.28; P < 0.03) associated with lower HbA(1c). In the subsample (n = 88), all self-reports were significantly (r = 0.35 to 0.55; P