Attenuation of human herpesvirus 6B reactivation by aging
Attenuation of human herpesvirus 6B reactivation by aging
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DOI：
10.1002/jmv.25434
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发表时间：
2019-07-01
影响因子：
12.7
通讯作者：
Yanagisawa, Hiroyuki
中科院分区：
文献类型：
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作者：
Kobayashi, Nobuyuki;Nishiyama, Toshiko;Yanagisawa, Hiroyuki
目的：关于人类疱疹病毒6 B（HHV-6 B）在健康成人中的研究很少，不同年龄组的患病率也不清楚。因此，本研究的主要目的是评估普通工作人群中HHV-6抗体的血清阳性率，并检查年龄对血清阳性率的影响。此外，作为HHV-6 B在唾液中重新激活，另一个目的是调查年龄和HHV-6 B重新激活之间的关联，根据测量唾液HHV-6 DNA levels.Methods：我们的研究对象是77名普通的办公室工作人员进行了健康检查。在这个人群中，我们使用酶联免疫吸附试验和唾液HHV-6 DNA水平测量抗HHV-6抗体滴度。除了检查与年龄的关联，我们研究了与身体质量指数，吸烟习惯，酒精消费的混杂factors.Results：有一个显着下降的HHV-6抗体的血清阳性受试者的50岁及以上，年龄显着负相关的抗HHV-6抗体滴度。年龄和唾液HHV-6 DNA水平也呈显着负相关，但没有显着相关性与其他factor.Conclusions：我们的研究结果表明，HHV-6 B再激活衰减老化。因此，HHV-6抗体在体内随着年龄的增长而稳步下降。
Objective: There has been little research on human herpesvirus 6B (HHV-6B) in healthy adults and prevalences in different age groups have been unclear. Therefore, the major objective of this study was to evaluate seroprevalence to HHV-6 antibodies in ordinary working people and examine the effect of aging on seroprevalence. Also, as HHV-6B is reactivated in saliva, another objective was to investigate an association between age and HHV-6B reactivation based on measured salivary HHV-6 DNA levels.Methods: Our subjects were 77 ordinary office workers who underwent a health checkup. In this population, we measured anti-HHV-6 antibody titers using enzyme-linked immunosorbent assay and salivary HHV-6 DNA levels. In addition to examining an association with age, we examined associations with body mass index, smoking habit, and alcohol consumption as confounding factors.Results: There was a significant decrease in the seropositivity of HHV-6 antibodies in subjects of 50 years and older, and age was significantly negatively correlated with anti-HHV-6 antibody titers. Age and salivary HHV-6 DNA levels were also significantly negatively correlated but there were no significant correlations with other factors.Conclusions: Our results suggest that HHV-6B reactivation is attenuated by aging. Thus, HHV-6 antibodies steadily decrease in the body with aging.