Jerte Valley cherry-based product modulates serum inflammatory markers in rats and ringdoves
Jerte Valley cherry-based product modulates serum inflammatory markers in rats and ringdoves
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DOI：
10.2478/v10136-011-0009-0
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发表时间：
2012-01-01
期刊：
影响因子：
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通讯作者：
Beatriz Rodriguez, Ana
中科院分区：
文献类型：
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作者：
Delgado, Jonathan;del Pilar Terron, Maria;Beatriz Rodriguez, Ana
衰老通常伴随着慢性亚临床炎症状态，与免疫功能障碍共存。食用富含抗氧化剂的食物与慢性病的发病率较低有关。本研究的目的是评估在两种不同的动物物种：大鼠和ringdoves（Streptopelia risoria）中食用Jerte Valley樱桃饮料对炎症负荷的影响;每种动物分为两个年龄组。为此目的，在用Jerte Valley樱桃饮料治疗10天之前和之后测量促炎（IL-1 β和TNF-α）和抗炎（IL-4和IL-2）细胞因子的循环水平。我们的研究结果表明，用Jerte Valley樱桃饮料进行10天的治疗，通过下调促炎（IL-1 β和TNF-α）细胞因子的水平和上调抗炎（IL-4和IL-2）细胞因子的水平，调节了大鼠和环鸽中促炎和抗炎细胞因子的平衡。此外，老年动物显示出炎症标志物水平不平衡，处于促炎状态，从而强调了衰老通常伴随着全身性炎症和炎症相关慢性疾病的事实。总之，由于植物来源的生物活性化合物的饮食摄入量增加可以延缓与年龄相关的免疫功能障碍并延长寿命，因此用基于樱桃的饮料补充饮食可以通过调节某些炎症标志物的血清浓度来减少炎症负荷。
Ageing is commonly accompanied by a chronic subclinical inflammatory status that coexists with immune dysfunction. Consumption of foods rich in antioxidants is associated with a lower incidence of chronic diseases. The aim of this study was to evaluate the effect of the consumption of a Jerte Valley cherry-based beverage on the inflammatory load in two different animal species: rats and ringdoves (Streptopelia risoria); each divided into two age groups. To this purpose, circulating levels of both pro-inflammatory (IL-1 beta and TNF-alpha) and anti-inflammatory (IL-4 and IL-2) cytokines were measured before and after a 10-day treatment with the Jerte Valley cherry-based beverage. Our results suggest that the 10-day treatment with the Jerte Valley cherry-based beverage modulated the balance of pro-and anti-inflammatory cytokines in both rats and ringdoves by down-regulating the levels of pro-inflammatory (IL-1 beta and TNF-alpha) cytokines and up-regulating the levels of anti-inflammatory (IL-4 and IL-2) cytokines. Moreover, old animals showed imbalanced levels of inflammatory markers towards a pro-inflammatory status, thereby underlining the fact that ageing is usually accompanied by systemic inflammation and inflammation-related chronic diseases. In conclusion, since an increased dietary intake of vegetable-derived bioactive compounds may retard age-related immune dysfunctions and prolong life-span, supplementing diets with the cherry-based beverage may reduce the inflammatory load by modulating the serum concentrations of some markers of inflammation.