Depression and anxiety symptoms are related to increased 24-hour urinary norepinephrine excretion among healthy middle-aged women
Depression and anxiety symptoms are related to increased 24-hour urinary norepinephrine excretion among healthy middle-aged women
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DOI：
10.1016/j.jpsychores.2004.02.016
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发表时间：
2004-10-01
影响因子：
4.7
通讯作者：
Sherwood, A
中科院分区：
文献类型：
--
作者：
Hughes, JW;Watkins, L;Sherwood, A
目的：抑郁是多种人群发病和死亡的危险因素，焦虑也与心脏病患者的死亡风险相关。自主神经系统功能障碍可能与这种风险有关。本研究的主要目的是评估自我报告的抑郁和焦虑症状水平与 24 小时尿儿茶酚胺排泄量之间的关系。方法：对 91 名 47-55 岁的女性进行了评估。抑郁症状通过贝克抑郁量表（BDI）进行评估，状态焦虑通过斯皮尔伯格状态特质焦虑量表（STAI）的状态焦虑部分（SAI）进行评估。对二十四小时收集的尿液进行肾上腺素 (EPI)、去甲肾上腺素 (NE) 和皮质醇 (CORT) 的检测。 EPI、NE 和 CORT 按体表面积进行索引，以控制体型的个体差异。结果：较高水平的抑郁症状与 24 小时 NE 排泄增加相关（r = .27，P = .009），抑郁女性（n = 17，BDI 评分大于或等于 10）的尿 NE 排泄率比 BDI 评分 < 10 的女性（n = 74）高约 25%，P = .007。较高水平的状态焦虑也与较多的 NE 排泄相关 (r = .28, P = .01)，CORT 排泄与抑郁 (r = .23, P = .02) 和焦虑 (r = .22, P = .04) 相关。抑郁和焦虑症状与尿 EPI 排泄无关。结论：目前的研究结果表明，女性中较高水平的抑郁和焦虑症状与 24 小时尿液 NE 和 CORT 排泄增加有关，这表明抑郁和焦虑可能与交感神经系统 (SNS) 活动增加有关，并且与 SNS 活动可能在社区老年人抑郁相关死亡率增加中发挥作用的可能性一致。 (C) 2004 Elsevier Inc. 保留所有权利。
Objective: Depression is a risk factor for morbidity and mortality in a variety of populations, and anxiety has also been associated with risk of mortality among cardiac patients. Dysfunction of the autonomic nervous system may be involved in this risk. The primary goal of this study was to evaluate the relationship between levels of self-reported symptoms of depression and anxiety and 24-hour urinary catecholamine excretion. Method: Ninety-one women aged 47-55 years were evaluated. Depression symptoms were assessed with the Beck Depression Inventory (BDI) and state anxiety was assessed with the state anxiety portion (SAI) of the Spielberger State-Trait Anxiety Inventory (STAI). Twenty-four hour urine collections were assayed for epinephrine (EPI), norepinephrine (NE) and cortisol (CORT). EPI, NE and CORT were indexed by body surface area to control for individual differences in body size. Results: Higher levels of depression symptoms were associated with increased 24-hour NE excretion (r = .27, P = .009), with depressed women (n = 17, BDI scores greater than or equal to 10) exhibiting an approximately 25% higher rate of urinary NE excretion than women with BDI scores < 10 (n = 74), P = .007. Higher levels of state anxiety were also related to greater NE excretion (r = .28, P = .01), and CORT excretion was related to both depression (r = .23, P = .02) and anxiety (r = .22, P = .04). Depression and anxiety symptoms were unrelated to urinary EPI excretion. Conclusions: The current findings that higher levels of depression and anxiety symptoms are related to increased 24-hour urinary NE and CORT excretion among women suggests that depression and anxiety may be associated with increased sympathetic nervous system (SNS) activity, and are consistent with the possibility that SNS activity may play a role in the increased mortality associated with depression in community-dwelling older adults. (C) 2004 Elsevier Inc. All rights reserved.