THE HYPNOZOITE AND RELAPSE IN PRIMATE MALARIA
THE HYPNOZOITE AND RELAPSE IN PRIMATE MALARIA
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DOI：
10.1128/cmr.5.1.26-35.1992
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发表时间：
1992-01-01
影响因子：
36.8
通讯作者：
COGSWELL, FB
中科院分区：
文献类型：
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作者：
COGSWELL, FB
虽然疟疾复发的现象古人已经知道，但其机制直到最近才得到令人满意的解释。长久以来认为灵长类疟疾的组织“周期”是复发原因的假说与临床和实验观察不符。疟原虫的潜伏期。在肝脏中，目前已有广泛的形态学和实验证实，最好地解释了间日疟原虫的复发现象和较长的潜伏期。这些潜伏期(催眠虫)已在三种复发性疟疾中被检测到，并被发现在接种子孢子后作为单核寄生虫在肝脏中持续存在长达229天。在两种疟原虫的体外培养中发现了它们，并对它们的超微结构进行了部分描述。
Although the phenomenon of malarial relapse was known to the ancients, the mechanism has only recently been explained satisfactorily. The long-held hypothesis of a tissue "cycle" in primate malaria as a cause of relapse did not fit clinical and experimental observations. A latent stage for Plasmodium spp. in the liver, for which there is now extensive morphological and experimental confirmation, best explains both the relapse phenomenon and the long prepatent periods seen with some strains of Plasmodium vivax. These latent stages (hypnozoites) have been detected in three relapsing malarias and have been found to persist in the liver as uninucleate parasites for up to 229 days after sporozoite inoculation. They have been found in in vitro cultures of two species of Plasmodium, and their ultrastructure has been partially described.