Effect of Mukitake mushroom (Panellus serotinus) on the pathogenesis of lipid abnormalities in obese, diabetic ob/ob mice.
Effect of Mukitake mushroom (Panellus serotinus) on the pathogenesis of lipid abnormalities in obese, diabetic ob/ob mice.
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DOI：
10.1186/1476-511x-12-18
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发表时间：
2013-02-14
影响因子：
4.5
通讯作者：
Yanagita T
中科院分区：
文献类型：
--
作者：
Inoue N;Inafuku M;Shirouchi B;Nagao K;Yanagita T
在东方国家，各种蘑菇在民间医学中被用于治疗生活方式疾病，并且已经分离出几种调节免疫系统、降低血脂水平、抑制肿瘤和病毒作用的化合物。Panellus sertinus （Mukitake）的子实体在日本被认为是最美味的食用蘑菇之一，之前的研究已经证明，膳食摄入粉状的全木竹或木竹提取物可以预防瘦素抗性db/db小鼠的非酒精性脂肪性肝病（NAFLD）的发展。在本研究中，我们评估了Mukitake饮食对瘦素缺乏的ob/ob小鼠代谢紊乱发病机制的影响。饲喂4周后，与对照组小鼠相比，木木克饲喂的ob/ob小鼠肝脏肿大、肝脏脂质积累和血清中肝损伤标志物升高明显减轻。此外，对照组ob/ob小鼠的轻度高脂血症减轻，木木克喂养的ob/ob小鼠的动脉粥样硬化指数升高。这些影响部分归因于Mukitake饮食抑制了肝脏脂肪生成酶活性。目前的研究结果表明，Mukitake补充剂有助于减轻肥胖、糖尿病ob/ob小鼠的NAFLD和血脂异常。
Various mushrooms have been used in folk medicine for the treatment of lifestyle diseases in eastern countries, and several compounds that modulate the immune system, lower blood lipid levels, and inhibit tumor and viral action have been isolated. The fruiting body of Panellus serotinus (Mukitake) is recognized in Japan as one of the most delicious edible mushrooms, and previous studies have demonstrated that the dietary intake of powdered whole Mukitake or Mukitake extracts prevents the development of non-alcoholic fatty liver disease (NAFLD) in leptin-resistant db/db mice. In the present study, we evaluated the effect of the Mukitake diet on the pathogenesis of metabolic disorders in leptin-deficient ob/ob mice. After 4 weeks of feeding, hepatomegaly, hepatic lipid accumulation, and elevated hepatic injury markers in the serum were markedly alleviated in Mukitake-fed ob/ob mice compared with control mice. Moreover, the mild hyperlipidemia in control ob/ob mice was attenuated and the elevated atherogenic index was reduced in Mukitake-fed ob/ob mice. These effects were partly attributable to the suppression of hepatic lipogenic enzyme activity due to the Mukitake diet. The current results showed that Mukitake supplementation is beneficial for the alleviation of NAFLD and dyslipidemia in obese, diabetic ob/ob mice.