Inflammatory markers in late-life depression: Results from a population-based study
Inflammatory markers in late-life depression: Results from a population-based study
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DOI：
10.1016/j.jad.2007.07.002
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发表时间：
2008-03-01
影响因子：
6.6
通讯作者：
Hoogendijk, W. J. G.
中科院分区：
文献类型：
--
作者：
Bremmer, M. A.;Beekman, A. T. F.;Hoogendijk, W. J. G.
背景：先前的研究报道了关于几种炎症标志物与抑郁症之间关系的相互矛盾的结果。炎症和抑郁症之间的关联可能取决于特定的慢性疾病的存在或相关的抑郁症patients only.Objective：为了评估炎症标志物和抑郁症之间的关联在老年人，考虑到混淆和效果修改factors.Method：人口为基础的研究1285参与者的纵向老龄化研究阿姆斯特丹，年龄65岁及以上。测定血浆白细胞介素-6（IL-6）和C反应蛋白（CRP）浓度。评估了重度抑郁症（首次或复发）和阈下抑郁症。调整了混杂变量的相关性。与炎症标志物的协会进一步研究了抑郁症的严重程度和持续时间方面，并就具体的抑郁symptoms.Results：高水平的IL-6（高于5 pg/mL）与抑郁症（比值比2.49（1.07-5.80），在复发和首次发作。没有发现任何一种标记物对抑郁症的特定症状维度有显著影响。（高于3.2 mg/L）与更高的CES-D评分相关，但在校正年龄和慢性疾病的混杂效应后则不相关。局限性：横断面设计限制了关于因果关系的结论。高血浆IL-6水平，而不是CRP，与老年人中重度抑郁症的患病率增加相关，与年龄，慢性疾病，认知功能和抗抑郁药无关。目前的研究结果为预防抑郁症的身体后果的临床研究提出了新的方向。(c)2007 Elsevier B. V.保留所有权利。
Background: Previous studies have reported conflicting results concerning the association between several inflammatory markers and depression. The association between inflammation and depression may depend on the presence of specific chronic diseases or be relevant in specific sub-groups of depressed patients only.Objective: To assess associations between inflammatory markers and depression in older people, taking account of confounding and effect-modifying factors.Method: Population-based study of 1285 participants of the Longitudinal Aging Study Amsterdam, aged 65 and over. Plasma concentrations of Interleukin-6 (IL-6) and C-reactive protein (CRP) were measured. Major depression (first- or recurrent episode) and sub-threshold depression were assessed. Associations were adjusted for confounding variables. Associations with inflammatory markers were further studied with regard to severity and duration of depression, and with regard to specific depressive symptoms.Results: High levels of IL-6 (above 5 pg/mL) were associated with major depression (odds ratio 2.49 (1.07-5.80), both in recurrent and first episodes. No significant effect of either one of the markers on specific symptom dimensions of depression was found. Mildly elevated plasma levels of CRP (above 3.2 mg/L) were associated with higher CES-D scores, but not after correction for the confounding effect of age and chronic diseases.Limitations: The cross-sectional design limits conclusions regarding causality.Conclusions: A high plasma level of IL-6, but not CRP, is associated with an increased prevalence of major depression in older people, independent of age, chronic diseases, cognitive functioning and anti-depressants. Present results suggest new directions for clinical research into the prevention of physical consequences of depression. (c) 2007 Elsevier B.V. All rights reserved.