Induction of tubulin polymerization and apoptosis in malignant mesothelioma cells by a new compound JBIR-23
Induction of tubulin polymerization and apoptosis in malignant mesothelioma cells by a new compound JBIR-23
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DOI：
10.1016/j.canlet.2010.10.005
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发表时间：
2011-01-28
期刊：
影响因子：
9.7
通讯作者：
Shin-ya, Kazuo
中科院分区：
文献类型：
--
作者：
Hwang, Ji-Hwan;Takagi, Motoki;Shin-ya, Kazuo
恶性胸膜间皮瘤（Malignant pleural mesothelioma，MPM）是一种高度侵袭性的肿瘤，预后差，因此需要开发新的治疗药物来治疗它。我们最近报道了一种新的抗MPM化合物，命名为JBIR-23。M停滞，随后通过p38丝裂原活化蛋白激酶和c-jun N-末端激酶的磷酸化经由半胱天冬酶途径诱导细胞凋亡。此外，体内分析表明，JBIR-23可预防荷瘤裸鼠的肿瘤生长，且无明显副作用（C）2010 Elsevier爱尔兰有限公司版权所有
Malignant pleural mesothelioma (MPM) is a highly aggressive tumor with a poor prognosis Thus novel therapeutic agents need to be developed for treating it We recently reported the isolation of the novel anti-MPM compound designated as JBIR-23 from Strep tomyces sp AK-AB27 In this study JBIR-23 exerted its cytotoxic effect on MPM cells by promotion of tubulin polymerization and G(2)/M arrest which was followed by apoptosis induction via the caspase pathway through phosphorylation of p38 mitogen-activated protein kinase and c-jun N-terminal kinase Furthermore in vivo analysis demonstrated that JBIR-23 prevented tumor growth in tumor-bearing nude mice without evident side effects (C) 2010 Elsevier Ireland Ltd All rights reserved