The Protein Information Resource
The Protein Information Resource
复制标题
DOI：
10.1093/nar/gkg040
复制
发表时间：
2003-01-01
影响因子：
14.9
通讯作者：
Barker, WC
中科院分区：
文献类型：
--
作者：
Wu, CH;Yeh, LSL;Barker, WC
蛋白质信息资源（PIR）是蛋白质信息学的综合公共资源，支持基因组和蛋白质组学研究和科学发现。PIR维护蛋白质序列数据库（PSD），这是一个包含超过283 000个序列的注释蛋白质数据库，涵盖整个分类范围。族分类用于敏感识别、一致注释和注释错误检测。超家族策展定义签名域架构并对成员资格进行分类以改进自动分类。为了增加实验注释的数量，PIR开发了文献检索，映射和用户提交的书目系统，并对实验特征进行了引文的回顾性归因。PIR还维护NREF，非冗余参考数据库和iProClass，蛋白质家族，功能和结构信息的集成数据库。PIR-NREF提供及时和全面的蛋白质序列收集，目前包括来自PIR-PSD，SWISS-PROT，TrEMBL，RefSeq，GenPept和PDB的超过100万个条目。PIR网站（http：/ / pir.乔治城edu）将数据分析工具连接到基础数据库，用于信息检索和知识发现，具有交互式查询、序列和文本搜索的组合以及搜索结果的排序和视觉探索的功能。FTP网站提供免费下载PSD和NREF双周刊以及辅助数据库和文件。
The Protein Information Resource (PIR) is an integrated public resource of protein informatics that supports genomic and proteomic research and scientific discovery. PIR maintains the Protein Sequence Database ( PSD), an annotated protein database containing over 283 000 sequences covering the entire taxonomic range. Family classification is used for sensitive identification, consistent annotation, and detection of annotation errors. The superfamily curation defines signature domain architecture and categorizes memberships to improve automated classification. To increase the amount of experimental annotation, the PIR has developed bibliography system for literature searching, mapping, and user submission, and has conducted retrospective attribution of citations for experimental features. PIR also maintains NREF, non-redundant reference database, and iProClass, an integrated database of protein family, function, and structure information. PIR-NREF provides timely and comprehensive collection of protein sequences, currently consisting of more than 1 000 000 entries from PIR-PSD, SWISS-PROT, TrEMBL, RefSeq, GenPept, and PDB. The PIR web site ( http:/ / pir. georgetown. edu) connects data analysis tools to underlying databases for information retrieval and knowledge discovery, with functionalities for interactive queries, combinations of sequence and text searches, and sorting and visual exploration of search results. The FTP site provides free download for PSD and NREF biweekly releases and auxiliary databases and files.