The Effect of Negative Pressure Therapy on the Femoral Vein Blood Flow and Wall Structure
The Effect of Negative Pressure Therapy on the Femoral Vein Blood Flow and Wall Structure
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DOI：
10.1177/0003319708318376
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发表时间：
2009-06
期刊：
影响因子：
2.8
通讯作者：
C. Lioupis;T. Kotsis;C. Barbatis;E. Seretis;A. Nomikos;Irene Volondakis-Baltatzis;A. Papalois;V. Andrikopoulos;D. Leaper
中科院分区：
文献类型：
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作者：
C. Lioupis;T. Kotsis;C. Barbatis;E. Seretis;A. Nomikos;Irene Volondakis-Baltatzis;A. Papalois;V. Andrikopoulos;D. Leaper
负压治疗最近已被用于管理淋巴或感染腹股沟并发症。本研究的目的是调查在腹股沟区应用负压治疗与深静脉血栓形成之间的任何可能的关联。在7只猪的腹股沟区域创建急性手术伤口。在股血管上直接施加-50至-200 mmHg的不同负压，并使用多普勒超声研究血流变化。治疗12小时后，还取出股静脉标本进行组织学检查。已经证明，负压治疗不会显著改变基线下肢静脉回流。组织学显示了几种与静脉血栓形成相关的变化。血流动力学和病理学结果仍然存在负压治疗血栓形成效应的可能性，需要注意保护股静脉，并采取血栓形成预防措施。
Negative pressure therapy has been recently used for managing lymphatic or infective groin complications. The aim of this study was to investigate any possible association between application of negative pressure therapy in the groin area and deep-vein thrombosis. Acute surgical wounds were created at the inguinal areas in 7 pigs. Different negative pressures ranging from −50 to −200 mmHg were applied directly over the femoral vessels, and blood flow alterations were studied using a Doppler ultrasound. Femoral vein specimens were also removed for histological examination after 12 hours of therapy. It has been demonstrated that negative pressure therapy does not significantly alter the baseline lower limb venous return. Histology demonstrated several changes, which are associated with vein thrombogenesis. The hemodynamic and pathological findings still leave a potential for thrombogenic effects of negative pressure therapy and warrant care to protect the femoral veins, with the use of thrombosis prophylaxis measures.