An activatable nanocomposite as a hydrogen peroxide-catalytic oxygenerator for tumor imaging and enhanced photodynamic therapy
An activatable nanocomposite as a hydrogen peroxide-catalytic oxygenerator for tumor imaging and enhanced photodynamic therapy
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DOI：
10.1016/j.snb.2023.133663
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发表时间：
2023-06
期刊：
影响因子：
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通讯作者：
Yan Huang;Lili Fu;Junjun Hou;Lingxiao Wang;Mingzhao Sun;Xiao Sun;Xiaoyan Wang;Lingxin Chen
中科院分区：
文献类型：
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作者：
Yan Huang;Lili Fu;Junjun Hou;Lingxiao Wang;Mingzhao Sun;Xiao Sun;Xiaoyan Wang;Lingxin Chen
光动力疗法已应用于多种肿瘤的治疗，具有高度的抑瘤性和较低的毒副作用。然而，肿瘤组织典型的低氧微环境长期以来一直是限制肿瘤光动力疗法疗效的关键因素。在这里，我们设计并合成了一种纳米复合材料RCDS@MnO2，将红色发射碳点(RCDS)与二氧化锰纳米片(MnO2)复合，用于催化过氧化氢(H_2O_2)产生O2，以改善肿瘤的缺氧环境。RCDS前驱体在可见光-近红外区(400-800 nm)有较宽的吸收带，并有红光发射(500-800 nm，峰值位于640 nm)。所制备的RCDS可在550 nm激光照射下产生1O2，达到光动力治疗的目的。此外，MnO2还可以猝灭RCDS的荧光发射，并在肿瘤细胞和组织中表现出RCDS@MnO2的荧光关闭-开启功能。RCDS@MnO2可以实现肿瘤细胞和肿瘤组织的荧光成像，改善肿瘤的缺氧环境，增强光动力治疗效果。RCDS@MnO2在体内外的研究表明，RCDS@MnO2具有应用于肿瘤组织荧光成像的强大潜力，并显著改善肿瘤的光动力学治疗。
Photodynamic therapy has been used in the treatment of a variety of tumors, with a high degree of tumor inhibition and reduced side effects. However, the typically hypoxic micro-environment of tumor tissue has long been a key factor limiting the efficacy of tumor photodynamic therapy. Here, we designed and synthesized a nanocomposite RCDs@MnO2, which compounded red emissive carbon-dots (RCDs) with manganese dioxide nanosheets (MnO2), for catalyzes hydrogen peroxide (H2O2) to produce O2to improve tumor hypoxic environment. The precursor of RCDs showing a wide absorption band in the visible to near-infrared region (400–800 nm) with red emission (from 500 to 800 nm, peaking at 640 nm). These prepared RCDs could produce1O2under 550 nm laser irradiation to achieve the purpose of photodynamic therapy. In addition, MnO2could quench the fluorescence emission of RCDs and exhibit an RCDs@MnO2fluorescence “off-on” function in tumor cells and tissues. RCDs@MnO2could achieve the fluorescence imaging of tumor cells and tumor tissues, and improve the tumor hypoxic environment and enhance photodynamic treatment effect. RCDs@MnO2has the powerful potential to be applied to fluorescence imaging of tumor tissue and significantly improve the photodynamic therapy of tumor, when investigated in vitro and in vivo.