Increased expression of aquaporin 1 in human hemangioblastomas and its correlation with cyst formation
Increased expression of aquaporin 1 in human hemangioblastomas and its correlation with cyst formation
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DOI：
10.1007/s11060-005-9057-1
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发表时间：
2006-12-01
影响因子：
3.9
通讯作者：
Takahashi, Jun A.
中科院分区：
文献类型：
--
作者：
Chen, Yizhao;Tachibana, Osamu;Takahashi, Jun A.
水通道蛋白（Aquaporins，AQP）是一个促进水分子跨膜流动的水通道家族。近年来，研究发现水通道蛋白1（AQP1）的表达不仅参与水的运输，而且参与肿瘤的发生。在本研究中，我们分析了水通道蛋白1在26例人类血管母细胞瘤中的表达。与对照组相比，血管母细胞瘤中AQP1表达显著上调（P = 0.002）。在血管母细胞瘤中，AQP1的表达主要定位于间质细胞的膜上。AQP1在囊性组血管母细胞瘤中的表达明显高于实性组（P = 0.021）。血管母细胞瘤内皮细胞AQP1表达阴性。这些结果表明，AQP1在基质细胞中的表达增加可能在血管母细胞瘤的囊肿形成和肿瘤发生中起作用。
Aquaporins (AQPs) is a water channel family which facilitates the passage of water across cell membranes. Recently, expression of aquapporin 1 (AQP1) was found to be involved in not only water transport but also tumorigenesis. In present study, we analyzed the expression of AQP1 in 26 consecutive cases of human hemangioblastomas. Significant upregulation of AQP1 expression was found in hemangioblastomas compared with control brain (P = 0.002). In hemangioblastomas, expression of AQP1 was predominantly localized on membranes of stromal cells. The expression level of AQP1 in cystic group of hemangioblastomas is much higher than that of solid group (P = 0.021). Most hemangioblastomas showed a negative expression of AQP1 on endothelial cells. These results imply that increased expression of AQP1 in stromal cells may play a role in cyst formation and tumorigenesis of hemangioblastomas.