Risk factors associated with symptoms of gastroesophageal reflux
Risk factors associated with symptoms of gastroesophageal reflux
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DOI：
10.1016/s0002-9343(99)00121-7
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发表时间：
1999-06-01
影响因子：
5.9
通讯作者：
Melton, LJ
中科院分区：
文献类型：
--
作者：
Locke, GR;Talley, NJ;Melton, LJ
背景：虽然胃食管反流患者经常被告知要改变他们的生活方式，但美国缺乏基于人群的反流危险因素数据。方法：我们对明尼苏达州奥姆斯特德县人口的年龄和性别分层随机样本进行了横断面研究。年龄在25岁至74岁之间的居民邮寄了一份有效的自我报告问卷，测量反流症状和潜在的危险因素。使用Logistic回归来估计与潜在危险因素相关的反流症状（胃灼热或反酸）的95%置信区间（CI）的比值比（OR）。结果：总体而言，2,118名符合条件的受试者中有1,524名（72%）做出了回应。身体质量指数> 30公斤/ m (2) (OR = 2.8; CI, 1.7 - 4.5),立即报告家庭成员与胃灼热或食道或胃的疾病(OR = 2.6; CI, 1.8 - 3.7),过去吸烟史(OR = 1.6; CI, 1.1 - 2.3),每周食用超过七杯(OR = 1.3; CI, 1.1 - 3.3),和更高的心身症状清单分数(或每5单位= 1.4;CI, 1.3 - 1.6)分别与有关频繁(至少每周一次)返流症状。结论：肥胖是胃食管反流的一个重要危险因素，尽管减肥的价值仍有待证实。家族史也是一个风险因素，这表明这种疾病可能有遗传因素。医学杂志。1999；106:642 - 649。(C) 1999年出版的医学摘录公司
BACKGROUND: Although patients with gastroesophageal reflux are often instructed to change their lifestyle, population-based data on the risk factors for reflux in the United States are lacking.METHODS: We performed a cross-sectional study in an age- and gender-stratified random sample of the population of Olmsted County, Minnesota. Residents aged 25 to 74 years were mailed a valid self-report questionnaire that measured reflux symptoms and potential risk factors. Logistic regression was used to estimate the odds ratios (OR) with 95% confidence intervals (CI) for reflux symptoms (heartburn or acid regurgitation) associated with potential risk factors.RESULTS: Overall, 1,524 (72%) of 2,118 eligible subjects responded. A body mass index >30 kg/m(2) (OR = 2.8; CI, 1.7 to 4.5), reporting an immediate family member with heartburn or disease of the esophagus or stomach (OR = 2.6; CI, 1.8 to 3.7), a past history of smoking (OR = 1.6; CI, 1.1 to 2.3), consuming more than seven drinks per week (OR = 1.3; CI, 1.1 to 3.3), and a higher psychosomatic symptom checklist score (OR per 5 units = 1.4; CI, 1.3 to 1.6) were independently associated with frequent (at least weekly) reflux symptoms.CONCLUSION: Obesity is a strong risk factor for gastroesophageal reflux, although the value of weight reduction remains to be proven. That family history was also a risk factor suggests that there may be a genetic component to the disorder. Am J Med. 1999;106:642- 649. (C) 1999 by Excerpta Medica, Inc.