Ir-Catalyzed Reversible Acceptorless Dehydrogenation/Hydrogenation of N-Substituted and Unsubstituted Heterocycles Enabled by a Polymer-Cross-Linking Bisphosphine
Ir-Catalyzed Reversible Acceptorless Dehydrogenation/Hydrogenation of N-Substituted and Unsubstituted Heterocycles Enabled by a Polymer-Cross-Linking Bisphosphine
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聚合物交联双膦实现 N-取代和未取代杂环的 Ir 催化可逆无受体脱氢/氢化
DOI：
10.1021/acs.orglett.0c01905
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发表时间：
2020
期刊：
影响因子：
5.2
通讯作者：
Sawamura Masaya
中科院分区：
文献类型：
--
作者：
Zhang Deliang;Iwai Tomohiro;Sawamura Masaya
聚苯乙烯交联型双膦配体PS-DPPBz对Ir催化的n-杂环的可逆无受体脱氢/加氢反应是有效的。值得注意的是，该方案适用于具有不同电子性质和空间性质的N-取代吲哚衍生物的脱氢反应。提出了N-取代底物的脱氢反应途径，即N-邻位C(SP3)-H键与双膦配位Ir(I)中心的氧化加成反应。
The polystyrene-cross-linking bisphosphine ligand PS-DPPBz was effective for the Ir-catalyzed reversible acceptorless dehydrogenation/hydrogenation ofN-heterocycles. Notably, this protocol is applicable to the dehydrogenation of N-substituted indoline derivatives with various N-substituents with different electronic and steric natures. A reaction pathway involving oxidative addition of an N-adjacent C(sp3)–H bond to a bisphosphine-coordinated Ir(I) center is proposed for the dehydrogenation of N-substituted substrates.