Intravitreal ganciclovir concentration after intravenous administration in AIDS patients with cytomegalovirus retinitis: implications for therapy.
Intravitreal ganciclovir concentration after intravenous administration in AIDS patients with cytomegalovirus retinitis: implications for therapy.
复制标题
患有巨细胞病毒性视网膜炎的艾滋病患者静脉注射后玻璃体内更昔洛韦浓度：对治疗的影响。
DOI：
10.1093/infdis/168.6.1506
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Freeman,WR
中科院分区：
文献类型：
--
作者：
Kuppermann,BD;Quiceno,JI;Flores-Aguilar,M;Connor,JD;Capparelli,EV;Sherwood,CH;Freeman,WR
To determine whether therapeutic intravitreal concentrations of ganciclovirare achieved after intravenous administration, vitreous samples were obtained intraoperatively from 23 eyes of 22 AIDS patients with retinal detachments associated with cytomegalovirus (CMV) retinitis. The mean intravitreal ganciclovir concentration of all samples was 0.93 ± 0.39 µg/mL (3.6 ± 1.5 µM). This level is near the published trough serum concentrations obtained with every-12-h intravenous dosing and well below the peak. It is significantlybelow the concentration of ganciclovir required to achieve 50% of viral plaque formation for many human CMV strains. Only a small decrease in vitreous drug levelswas observed as a function of time after last dose. Intravenous administration of ganciclovir results in near-steady-state subtherapeutic intravitreal ganciclovir concentrations for many CMV isolates. This may explain the difficultyof long-term complete suppression of CMV retinitis.
