Emerging interactions between skin stem cells and their niches.
Emerging interactions between skin stem cells and their niches.
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作者：
皮肤保护哺乳动物免受伤害，感染和脱水，并使体温调节和感官知觉。各种皮肤驻留细胞执行这些不同的功能。细胞的不断更新和损伤后的愈合需要多个干细胞库。因此，皮肤为研究干细胞与其微环境或小生境之间的相互作用提供了模型。遗传和成像工具的进步带来了关于皮肤干细胞及其后代之间的谱系关系以及皮肤干细胞及其生态位之间的相互影响的新发现。这些知识可能为治疗和再生医学提供新的途径。
The skin protects mammals from insults, infection and dehydration and enables thermoregulation and sensory perception. Various skin-resident cells carry out these diverse functions. Constant turnover of cells and healing upon injury necessitate multiple reservoirs of stem cells. Thus, the skin provides a model for studying interactions between stem cells and their microenvironments, or niches. Advances in genetic and imaging tools have brought new findings about the lineage relationships between skin stem cells and their progeny and about the mutual influences between skin stem cells and their niches. Such knowledge may offer novel avenues for therapeutics and regenerative medicine.
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影响因子：
64.8
作者：
Chang, Chiung-Ying;Pasolli, H. Amalia;Giannopoulou, Eugenia G.;Guasch, Geraldine;Gronostajski, Richard M.;Elemento, Olivier;Fuchs, Elaine
通讯作者：
Fuchs, Elaine
影响因子：
23.9
作者：
Brownell, Isaac;Guevara, Elizabeth;Bai, C. Brian;Loomis, Cynthia A.;Joyner, Alexandra L.
通讯作者：
Joyner, Alexandra L.
影响因子：
64.8
作者：
Conboy, IM;Conboy, MJ;Rando, TA
通讯作者：
Rando, TA
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
64.5
作者：
Festa E;Fretz J;Berry R;Schmidt B;Rodeheffer M;Horowitz M;Horsley V
通讯作者：
Horsley V