Genetic studies in Parkinson's disease with an α-synuclein/NACP gene polymorphism in Japan
Genetic studies in Parkinson's disease with an α-synuclein/NACP gene polymorphism in Japan
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DOI：
10.1016/s0304-3940(01)01557-9
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发表时间：
2001-03-09
影响因子：
2.5
通讯作者：
Kawakami, H
中科院分区：
文献类型：
--
作者：
Izumi, Y;Morino, H;Kawakami, H
在 α-突触核蛋白 (α-SYN)/NAC 前体蛋白 (NACP) 基因的启动子中观察到二核苷酸重复多态性。据报道，α-SYN/NACP 等位基因 3（由 Xia 等人描述（Ann. Neurol., 40 (1996) 207），相当于 Krijger 等人描述的等位基因 1.（Ann. Neurol. 45 (1999) 611）在散发性帕金森病 (sPD) 患者中的出现频率显着高于对照组。在这项研究中，我们对相同的 α 进行了基因分型-日本 sPD 患者和健康对照中的 SYN/NACP 多态性，但发现两组之间的任何等位基因均无显着差异 (C) 2001 Elsevier Science Ireland Ltd. 保留所有权利。
Dinucleotide repeat polymorphism has been observed in the promoter of the alpha -synuclein (alpha -SYN)/NAC precursor protein (NACP) gene. alpha -SYN/NACP allele 3 (described by Xia et al. (Ann. Neurol., 40 (1996) 207), equivalent to allele 1 described by Krijger et a I. (Ann. Neurol. 45 (1999) 611) is reported to be significantly more frequent among patients with sporadic Parkinson's disease (sPD) than controls. In this study, we genotyped the same alpha -SYN/NACP polymorphism in Japanese sPD patients and healthy controls, but found that any allele showed no significant difference between the two groups. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.