Aspirin thromboprophylaxis in joint replacement surgery.
Aspirin thromboprophylaxis in joint replacement surgery.
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DOI：
10.1002/rth2.12649
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发表时间：
2022-01
影响因子：
4.6
通讯作者：
Bauer KA
中科院分区：
文献类型：
--
作者：
Sharda AV;Fatovic K;Bauer KA
在美国，阿司匹林通常被用作预防关节置换术后静脉血栓栓塞（VTE）的唯一药物。尽管如此，在真实的世界环境中，缺乏研究关节置换术中仅阿司匹林血栓预防后VTE事件的前瞻性研究。本研究的目的是评估关节置换术后仅阿司匹林药物预防的VTE风险。我们对350例接受全膝关节和全髋关节置换术的低风险患者（无VTE既往史和低心血管风险因素）进行了一项前瞻性观察性研究，术后仅接受阿司匹林预防血栓形成。3个月随访期间观察到的症状性静脉血栓栓塞风险为1.7%（95%置信区间，0.9%-3.3%），仅发生一起大出血事件，无手术血肿。在该真实的队列中，关节置换术中阿司匹林单药治疗预防血栓形成的VTE风险高于既往报告的风险。
Aspirin is commonly used as the only pharmacologic agent for prevention of venous thromboembolism (VTE) after joint replacement surgery in the United States. Despite this, prospective studies investigating VTE events after aspirin‐only thromboprophylaxis in joint replacement surgery are lacking in the real‐world setting. The aim of this study was to estimate the risk of VTE with aspirin‐only pharmacologic prophylaxis following joint replacement surgery. We carried out a prospective observational study of 350 low‐risk patients (no prior history of VTE and low cardiovascular risk factors) who underwent total knee and total hip arthroplasty and received only aspirin for thromboprophylaxis postoperatively. The observed risk of symptomatic VTE was 1.7% (95% confidence interval, 0.9%‐3.3%) over 3 months of follow up, with only one major bleeding event and no surgical hematomas. The risk of VTE with aspirin monotherapy for thromboprophylaxis in joint replacement surgery in this real‐world cohort was higher than previously reported.
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