Control of a genetic regulatory network by a selector gene
Control of a genetic regulatory network by a selector gene
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DOI：
10.1126/science.1058312
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发表时间：
2001-05-11
期刊：
影响因子：
56.9
通讯作者：
Carroll, SB
中科院分区：
文献类型：
--
作者：
Guss, KA;Nelson, CE;Carroll, SB
许多复杂结构的形成是由选择基因编码的一类特殊的转录因子控制的。研究表明，SCALLOPED是果蝇翅区选择蛋白复合物的DNA结合组分，它结合并直接调节控制翅发育的遗传调节网络中许多单个靶基因的顺式调节元件。此外，结合位点的SCALLOPED和信号传导途径的转录效应物的组合是必要的，足以指定翼特异性反应不同的信号传导途径。顺式调控DNA上选择子和信号蛋白输入的专性整合可能是选择子蛋白在发育过程中控制广泛的遗传调控网络的一般机制。
The formation of many complex structures is controlled by a special class of transcription factors encoded by selector genes. it is shown that SCALLOPED, the DNA binding component of the selector protein complex for the Drosophila wing field, binds to and directly regulates the cis-regulatory elements of many individual target genes within the genetic regulatory network controlling wing development. Furthermore, combinations of binding sites for SCALLOPED and transcriptional effecters of signaling pathways are necessary and sufficient to specify wing-specific responses to different signaling pathways. The obligate integration of selector and signaling protein inputs on cis-regulatory DNA may be a general mechanism by which selector proteins control extensive genetic regulatory networks during development.