Extrasegmental analgesia of heterotopic electroacupuncture stimulation on visceral pain rats
Extrasegmental analgesia of heterotopic electroacupuncture stimulation on visceral pain rats
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异位电针刺激内脏痛大鼠节段外镇痛
DOI：
10.1016/j.brainres.2010.12.013
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发表时间：
2011-02-10
期刊：
影响因子：
2.9
通讯作者：
Xu, Nenggui
中科院分区：
文献类型：
--
作者：
Liu, Jianhua;Fu, Wenbin;Xu, Nenggui
针灸治疗内脏痛在临床上应用已久。然而，其潜在机制仍然未知。本实验观察了电针口面穴对内脏痛大鼠的节段外镇痛作用。结果表明，电针刺激异位穴位或非穴位激活A（delta）和/或C纤维，可诱导三叉旁核（PTN）c-fos表达，并显著抑制醋酸引起的腹缩和孤束核（NTS）c-fos表达。然而，在异位穴位施加非伤害性EA或非EA刺激完全无效。经眶下神经切断或辣椒素预处理后，电针镇痛作用明显受到抑制。蛇毒预处理对这种镇痛作用无影响。因此，异位电针刺激触发了弥漫性伤害性抑制控制（DNIC）的疼痛抑制作用，其中PTN-NTS次级神经通路可能参与其中，并且小直径（A（δ）和/或C）纤维是至关重要的。(c)2010 Elsevier B. V.保留所有权利。
Acupuncture has been applied in the clinic to treat visceral pain for a long time. However, the underlying mechanism still remains unknown. In the present study, extrasegmental analgesia of electroacupuncture (EA) at orofacial acupoints on visceral pain rats was investigated. The results revealed that nociceptive EA stimulation applied at heterotopic acupoints or nonacupoints to activate A(delta) and/or C fibers induced c-fos expression in the paratrigeminal nucleus (PTN) and significantly inhibited acetic acid-induced abdominal contractions and c-fos expression in the nucleus of the solitary tract (NTS). However, non-nociceptive EA or non-EA stimulation applied at heterotopic acupoints was totally ineffective. After infraorbital nerves transaction or pretreated by capsaicin, the EA analgesia was dramatically inhibited. Snake venom pretreatment had no influence on this analgesia. Consequently, heterotopic EA stimulation trigger the pain-inhibiting effect of diffuse noxious inhibitory controls (DNIC), in which PTN-NTS secondary neural pathway may be involved and small-diameter (A(delta) and/or C) fibers are crucial. (c) 2010 Elsevier B.V. All rights reserved.