THE DEVELOPMENT OF MORPHINE-TOLERANCE AND DEPENDENCE IS ASSOCIATED WITH TRANSLOCATION OF PROTEIN-KINASE-C
THE DEVELOPMENT OF MORPHINE-TOLERANCE AND DEPENDENCE IS ASSOCIATED WITH TRANSLOCATION OF PROTEIN-KINASE-C
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DOI：
10.1016/0304-3959(95)00023-l
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发表时间：
1995-06-01
期刊：
影响因子：
7.4
通讯作者：
PRICE, DD
中科院分区：
文献类型：
--
作者：
MAYER, DJ;MAO, JR;PRICE, DD
The development of tolerance to the analgesic effects of morphine as well as morphine dependence were greatly reduced by co-administration with morphine of GM1 ganglioside, a substance reported to block the translocation of protein kinase C (PKC) from cytosol to membrane of neurons. Rats made tolerant to intrathecal administration of morphine showed increased membrane-bound PKC in the superficial layers (laminae I and II) of the spinal cord dorsal horn but not in deeper layers. This increase was prevented by co-administration with morphine of GM1 ganglioside. These results indicate that the translocation and activation of PKC may be a critical step in the development of opiate tolerance and dependence. Modulation of PKC translocation and activation may prove useful for the management of pain and opiate addiction.
