Cobalt(III)-Catalyzed 1,4-Addition of C(sp(3))-H Bonds to Maleimides
Cobalt(III)-Catalyzed 1,4-Addition of C(sp(3))-H Bonds to Maleimides
复制标题
钴 (III) 催化 C(sp(3))-H 键与马来酰亚胺的 1,4-加成
作者：
Chen Xiang Xiang;Ren Jiang Tao;Xu Jing Lei;Xie Hu;Sun Wei;Li Ya Min;Sun Meng
喹啉和琥珀酰亚胺在许多药物和天然产物中发挥着至关重要的作用。尽管 sp2C-H 键加成反应已被广泛研究，但 Co(III) 催化的 sp3C-H 键 1,4-加成反应相对尚未被探索。在这份手稿中，提出了一种有效且原子经济的 8-甲基喹啉与马来酰亚胺烷基化反应方案。该反应表现出优异的反应活性、令人满意的产率、优异的化学和区域选择性，并且耐受多种官能团。
Quinolines and succinimides play a crucial role in many pharmaceutical and natural products. Although sp2C–H bond addition reactions have been extensively investigated, Co(III)-catalyzed sp3C–H bond 1,4-addition reactions are relatively unexplored. In this manuscript, an efficient and atom-economic protocol for alkylation reactions of 8-methylquinolines with maleimides is presented. The reaction exhibits exceptional reactivity, satisfactory yields, excellent chemo- and regioselectivity, and tolerates a variety of functional groups.