Predictors of reduced relative dose intensity and its relationship to mortality in women receiving multi-agent chemotherapy for epithelial ovarian cancer
Predictors of reduced relative dose intensity and its relationship to mortality in women receiving multi-agent chemotherapy for epithelial ovarian cancer
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DOI：
10.1016/j.ygyno.2012.12.017
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发表时间：
2013-04-01
影响因子：
4.7
通讯作者：
Lyman, Gary H.
中科院分区：
文献类型：
--
作者：
Hanna, Rabbie K.;Poniewierski, Marek S.;Lyman, Gary H.
目标。关于实体瘤的相对剂量强度(RDI)对临床结果的影响的信息有限。本研究的目的是评价新诊断的晚期上皮性卵巢癌(EOC)铂类化疗患者RDI的预后意义以及RDI降低的预测因素。对1995-2009年间接受多药静脉化疗的FIGO III-IV期上皮性卵巢癌患者进行了一项多中心的回顾性研究。获得的数据包括最初实施的四个化疗周期。结果包括：(1)计划和交付的相对剂量强度(RDI)，(2)无进展(PFS)和总体(OS)生存。生存估计基于Kaplan和Meier方法，多因素分析基于Logistic回归和Cox比例风险回归。可评估的对象包括325名女性。中位随访34个月(0.4~170个月)，进展或复发241例(73.9%)，死亡179例(54.9%)。在多因素分析中，减少计划RDI的预测因素是：停止研究方案的治疗(优势比[OR]=4.3；P2 m(2)(OR=6.14；P
Objective. There is limited information concerning the role of relative dose intensity (RDI) on clinical outcomes in solid tumors. The objectives of our study were to evaluate the prognostic significance of RDI and predictors of reduced RDI in women with newly diagnosed advanced stage epithelial ovarian carcinoma (EOC) treated with platinum-based chemotherapy.Methods. A multi-center retrospective study of women with FIGO stage III-IV epithelial ovarian cancer treated postoperatively with multi-agent intravenous chemotherapy between 1995 and 2009 was conducted. Data were obtained to include the first four chemotherapy cycles administered. Outcomes included: (1) planned and delivered relative dose intensity (RDI), (2) progression-free (PFS) and overall (OS) survival. Survival estimates were based on Kaplan and Meier method, and multivariate analyses were based on logistic regression and Cox proportional hazards regression.Results. Evaluable subjects included 325 women. With median follow-up of 34 months (range, 0.4-170), progression or recurrence was recorded in 241 (73.9%) and death in 179 (54.9%). In multivariate analysis, predictors of reduced planned RDI were: treatment off research protocols (odds ratio [OR] = 4.3; P2 m(2) (OR = 6.14; P