Review of the human immune mechanisms directed against Entamoeba histolytica.
Review of the human immune mechanisms directed against Entamoeba histolytica.
复制标题
针对溶组织内阿米巴的人体免疫机制综述。
DOI：
10.1093/clinids/8.2.261
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Ravdin,JI
中科院分区：
文献类型：
--
作者：
Salata,RA;Ravdin,JI
人体免疫机制对破坏性寄生虫溶组织内阿米巴的有效性尚未建立。体液反应与侵袭性疾病有关，但与预防复发性侵袭性感染无关。虽然补体是杀阿米巴的，但阿米巴的侵袭性菌株可能具有抗药性。多态性中性粒细胞在体外对毒性阿米巴菌株没有活性，可能有助于疾病的发病机制。体外研究表明，人类活化的单核细胞衍生的巨噬细胞和细胞毒性T淋巴细胞是杀死有毒阿米巴的胜任细胞。可溶性阿米巴蛋白制剂对正常未感染的人淋巴细胞有促有丝分裂作用，这显然是因为存在N-乙酰-D-半乳糖胺可降解的阿米巴凝集素。尽管较低的T4：T8比值和异质性淋巴细胞增殖反应的有丝分裂原，阿米巴肝脓肿患者发展致敏阿米巴抗原和特定的效应机制。虽然抗体，补体，非免疫机制，以及寄生虫因素，可能是重要的，在确定侵袭性阿米巴病的发生，人类细胞介导的免疫机制可能发挥重要作用，在打击侵袭性感染，由于E。溶组织剂
The human immune mechanisms effective against the destructive parasiteEntamoeba histolyticahave not been established. Humoral responses develop with invasive disease but have not positively correlated with protection against recurrent invasive infection. Though complement is amebicidal, invasivestrains of amebas may be resistant. Polymorphonuclear neutrophils have not been active in vitro against virulent amebic strains and could contribute to the pathogenesis of disease. In vitro studies have shown human activated monocyte-derived macrophages and cytotoxic T lymphocytes to be competent cells in killing virulent amebas. Soluble amebic protein preparations have been shown to be mitogenic for normal, uninfected human lymphocytes, apparently because theN-acetyl-D- galactosamine-inhibitable amebic lectin is present. Despite a lower T4:T8 ratio and a heterogeneous lymphocyte proliferation in response to mitogens, patients with amebic hepatic abscess develop sensitization to amebic antigens and specific effector mechanisms. Although antibody, complement, and nonimmune mechanisms, as well as parasite factors, may be important in determining the occurrence of invasive amebiasis, human cellmediated immune mechanisms may playa major role in combating invasive infection due toE. histolytica.