Characterization of the NikA histidine kinase implicated in the phosphorelay signal transduction of Aspergillus nidulans, with special reference to fungicide responses
Characterization of the NikA histidine kinase implicated in the phosphorelay signal transduction of Aspergillus nidulans, with special reference to fungicide responses
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DOI：
10.1271/bbb.70051
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发表时间：
2007-03-01
影响因子：
1.6
通讯作者：
Mizuno, Takeshi
中科院分区：
文献类型：
--
作者：
Hagiwara, Daisuke;Matsubayashi, Yoshihiro;Mizuno, Takeshi
我们最近编制了一个完整的列表中的模式丝状真菌构巢曲霉磷酸化信号转导组件。在这项研究中，我们的特点是在许多真菌中发现的组氨酸蛋白激酶（命名为NikA），特别是对强效杀菌剂（异菌脲和咯菌腈）的反应。我们提供的证据表明，不仅NikA，而且两个下游反应调节剂（SskA和SrrA）是至关重要的参与这些杀真菌剂的作用模式，以及进一步下游的HogA-MAPK级联放大异常（或异位）在菌丝中的杀真菌剂的方式依赖于NikA-SskA phosphorelay。
We recently compiled a complete list of phosphorelay signal transduction components in the model filamentous fungus Aspergillus nidulans. In this study, we characterized a histidine protein kinase (designated NikA) that is found in many fungi, with special reference to responses to potent fungicides (iprodione and fludioxonil). We provided evidence that not only NikA, but also two downstream response regulators (SskA and SrrA) are crucially implicated in the mode of action of these fungicides, and also that the further downstream HogA-MAPK cascade is exaggerated abnormally (or ectopically) in hyphae by the fungicides in a manner dependent on the NikA-SskA phosphorelay.