VITamins And Lifestyle cohort study: Study design and characteristics of supplement users
VITamins And Lifestyle cohort study: Study design and characteristics of supplement users
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DOI：
10.1093/aje/kwh010
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发表时间：
2004-01-01
影响因子：
5
通讯作者：
Potter, JD
中科院分区：
文献类型：
--
作者：
White, E;Patterson, RE;Potter, JD
维生素和矿物质补充剂是美国最常用的药物之一，尽管关于其益处或风险的证据有限。本文介绍了VITALTM和生活方式（VITAL）研究的设计，实施和参与者的特征，这是一项关于补充剂使用与癌症风险之间关系的队列研究。2000-2002年，华盛顿州西部共有77，738名年龄在50-76岁之间的男性和女性通过完成有关补充剂使用、饮食和其他癌症风险因素的详细调查问卷进入该研究，其中70%的人通过自我收集的口腔细胞样本提供了DNA。补充剂使用者是招募的目标：66%使用多种维生素，46%使用单独的维生素C，47%使用单独的维生素E，46%使用钙，通常在过去10年中有5-8年。分析确定混杂因素，主要研究的局限性，表明定期使用非甾体抗炎药，水果和蔬菜的摄入量，以及娱乐性体力活动与补充剂的使用密切相关（p < 0.001）。作者描述了一个跟踪系统，其中癌症，死亡和居住地的变化被有效地跟踪，主要是通过与公共数据库的链接。这些方法可能对其他研究人员实施大型队列研究或设计被动随访系统有用。
Vitamin and mineral supplements are among the most commonly used drugs in the United States, despite limited evidence on their benefits or risks. This paper describes the design, implementation, and participant characteristics of the VITamins And Lifestyle (VITAL) Study, a cohort study of the associations of supplement use with cancer risk. A total of 77,738 men and women in western Washington State, aged 50-76 years, entered the study in 2000-2002 by completing a detailed questionnaire on supplement use, diet, and other cancer risk factors, and 70% provided DNA through self-collected buccal cell specimens. Supplement users were targeted in recruitment: 66% used multivitamins, 46% used individual vitamin C, 47% used individual vitamin E, and 46% used calcium, typically for 5-8 of the past 10 years. Analyses to identify confounding factors, the main study limitation, showed that regular nonsteroidal anti-inflammatory drug use, intake of fruits and vegetables, and recreational physical activity were strongly associated with supplement use (p < 0.001). The authors describe a follow-up system in which cancers, deaths, and changes of residence are tracked efficiently, primarily through linkage to public databases. These methods may be useful to other researchers implementing a large cohort study or designing a passive follow-up system.