EFFECT OF AGING ON VENTILATORY RESPONSE TO EXERCISE AND CO2
EFFECT OF AGING ON VENTILATORY RESPONSE TO EXERCISE AND CO2
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DOI：
10.1152/jappl.1984.56.5.1143
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发表时间：
1984-01-01
影响因子：
3.3
通讯作者：
PACK, AI
中科院分区：
文献类型：
--
作者：
BRISCHETTO, MJ;MILLMAN, RP;PACK, AI
在人类中研究了年龄对2种已知呼吸兴奋剂、吸入CO2和运动的呼吸反应性的影响。虽然运动呼吸过度发展的生理机制的解释仍然难以捉摸，但有很多间接证据表明，在运动过程中，无论如何介导，通气都与CO2的产生有关。研究年轻和老年受试者的匹配组以确定在稳态运动期间增加通气量和增加CO2产生（≥ VCO 2）之间的关系以及在CO2再呼吸期间响应于进行性高碳酸血症的他们的分钟通气量的变化。与年轻对照组相比，老年受试者对高碳酸血症的缓解反应的斜率降低（Δ.≥ VE/Δ PCO2 = 1.64 ±。0.21与2.44 .+-. 0.40 l. cntdot. min-1. mmHg-1，平均值±。分别）。在老年人中运动期间通气和CO2产生之间的关系的斜率大于年轻受试者（Δ. ovrhdot.VE/.DELTA.. vrhdot.VCO2 = 29.7 .+-。1.19对比25.3 .+-。1.54，平均值±。SE），如在单一工作负荷（50 W）下的分钟通气量（32.4 ± 0.01）。2.3与25.7 .+-相比。1.54 l/min，平均值±。分别）。老年人运动时通气量的增加不是由动脉氧饱和度下降引起的，增加的厌氧代谢也没有发挥作用。相反，运动期间增加的通气似乎补偿了气体交换的增加的无效性，使得运动基本上保持等二氧化碳。在老年人中，对高碳酸血症的缓解反应低于年轻受试者，而对运动的缓解反应更大。
The effects of aging on the ventilatory responsiveness to 2 known respiratory stimulants, inhaled CO2 and exercise were studied in humans. Although explanation of the physiological mechanisms underlying development of exercise hyperpnea remains elusive, there is much circumstantial evidence that during exercise, however mediated, ventilation is coupled to CO2 production. Matched groups of young and elderly subjects were studied to determine the relationship between increasing ventilation and increasing CO2 production (.ovrhdot.VCO2) during steady-state exercise and the change in their minute ventilation in response to progressive hypercapnia during CO2 rebreathing. The slope of the ventilatory response to hypercapnia was depressed in elderly subjects when compared with the younger control group (.DELTA..ovrhdot.VE/.DELTA.PCO2 = 1.64 .+-. 0.21 vs. 2.44 .+-. 0.40 l .cntdot. min-1 .cntdot. mmHg-1, means .+-. SE, respectively). The slope of the relationship between ventilation and CO2 production during exercise in the elderly was greater than that of younger subjects (.DELTA..ovrhdot.VE/.DELTA..ovrhdot.VCO2 = 29.7 .+-. 1.19 vs. 25.3 .+-. 1.54, means .+-. SE, respectively), as was minute ventilation at a single work load (50 W) (32.4 .+-. 2.3 vs. 25.7 .+-. 1.54 l/min, means .+-. SE, respectively). This increased ventilation during exercise in the elderly was not produced by arterial O2 desaturation and increased anaerobiasis did not play a role. Instead, the increased ventilation during exercise seems to compensate for increased inefficiency of gas exchange such that exercise remains essentially isocapnic. In the elderly, the ventilatory response to hypercapnia is less than in young subjects, whereas the ventilatory response to exercise is greater.