Expression of aquaporin-1 in normal, hyperplasic, and carcinomatous endometria
Expression of aquaporin-1 in normal, hyperplasic, and carcinomatous endometria
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水通道蛋白-1 在正常、增生和癌性子宫内膜中的表达
DOI：
10.1016/j.ijgo.2007.12.006
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发表时间：
2008-06-01
影响因子：
3.8
通讯作者：
Huang, He-Feng
中科院分区：
文献类型：
--
作者：
Pan, Hong;Sun, Chao-Chao;Huang, He-Feng
目的：探讨水通道蛋白-1 （AQP1）与子宫内膜腺癌的关系。方法：对117例子宫内膜样腺癌患者（75例）、子宫内膜增生患者（17例）和正常子宫内膜增生性患者（25例）的肿瘤内微血管密度（IMD）、AQP1和血管内皮生长因子（vegf）的表达进行检测。结果：AQP1位于上皮细胞。所有样本微血管和小血管细胞。AQP1/IMD比值在第一组样品中最高，第二组样品中较低，第三组样品中最低。在子宫内膜样腺癌样本中，AQP1/IMD比值与组织学分级、手术分期、子宫内膜浸润和子宫外转移显著相关。AQP1表达与IMID呈正相关，AQP1/IMD比值与VEGF表达呈正相关。结论：AQP1可能通过促进血管生成参与子宫内膜样腺癌的发生发展，AQP1水平可能既是肿瘤的指标，也是新的治疗靶点。(C) 2008年国际妇产科联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objective: To explore the relationship between aquaporin-1 (AQP1) and endometrial adenocarcinoma. Method: Intratumoral microvessel density (IMD) was assessed as well as AQP1 and vascular endothelial growth factor expression in samples from 117 women, 75 with endometrioid adenocarcinoma, 17 with endometrial hyperplasia, and 25 with normal proliferative endometria. Results: AQP1 was located in the epithelial. cells of microvessels and small vessels in all samples. The AQP1/IMD ratio was highest in samples from the first, less in samples from the second, and least in samples from the third group. In samples from endometrioid adenocarcinoma, the AQP1/IMD ratio was significantly correlated with histologic grade, surgical stage, myometrial invasion, and extrauterine metastasis. There was a positive correlation between AQP1 expression and IMID and between AQP1/IMD ratio and VEGF expression. Conclusion: AQP1 may be involved in the tumorigenesis and progression of endometrioid adenocarcinoma by promoting angiogenesis, and AQP1 level may be both a tumor indicator and a new therapeutic target. (C) 2008 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.