Producer T cells: Using genetically engineered T cells as vehicles to generate and deliver therapeutics to tumors.
Producer T cells: Using genetically engineered T cells as vehicles to generate and deliver therapeutics to tumors.
复制标题
生产者T细胞：使用基因工程的T细胞作为车辆来生成并为肿瘤提供治疗剂。
DOI：
10.1080/2162402x.2015.1122158
复制
发表时间：
2016-05
期刊：
影响因子：
7.2
通讯作者：
Davila E
中科院分区：
文献类型：
--
作者：
Tsai AK;Davila E
Adoptive cell transfer (ACT) is an emerging anticancer therapy that has shown promise in various malignancies. Redirecting antigen specificity by genetically engineering T cells to stably express receptors has become an effective variant of ACT. A novel extension of this approach is to utilize engineered T cells to produce and deliver anticancer therapeutics that enhance cytotoxic T cell function and simultaneously inhibit immunosuppressive processes. Here, we review the potential of using T cells as therapeutic-secreting vehicles for immunotherapies and present theoretical and established arguments in support of further development of this unique cell-based immunotherapy.
