The Generation R Study: Design and cohort profile
The Generation R Study: Design and cohort profile
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DOI：
10.1007/s10654-006-9022-0
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发表时间：
2006-06-01
影响因子：
13.6
通讯作者：
Hofman, Albert
中科院分区：
文献类型：
--
作者：
Jaddoe, Vincent W. V.;Mackenbach, Johan P.;Hofman, Albert
R世代研究是一项以人群为基础的前瞻性队列研究，从胎儿期到成年早期。该研究旨在确定从胎儿生命到成年早期正常和异常生长，发育和健康的早期环境和遗传原因。该研究侧重于四个主要研究领域：（1）生长和身体发育;（2）行为和认知发展;（3）儿童疾病;（4）孕妇和儿童的健康和保健。总共有9778名分娩日期从2002年4月到2006年1月的母亲参加了这项研究。在所有出生时符合条件的儿童中，61%参加了这项研究。产前阶段的数据收集包括体格检查、问卷调查、胎儿超声检查和生物样本。此外，还对1232名孕妇及其子女进行了更详细的评估。这些孩子形成了一个产前招募的出生队列，将被跟踪到成年早期。最终，R世代研究的结果必须有助于制定优化孕妇和儿童健康和保健的战略。
The Generation R Study is a population-based prospective cohort study from fetal life until young adulthood. The study is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health from fetal life until young adulthood. The study focuses on four primary areas of research: (1) growth and physical development; (2) behavioral and cognitive development; (3) diseases in childhood; and (4) health and healthcare for pregnant women and children. In total, 9778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Of all eligible children at birth, 61% participate in the study. Data collection in the prenatal phase included physical examinations, questionnaires, fetal ultrasound examinations and biological samples. In addition, more detailed assessments are conducted in a subgroup of 1232 pregnant women and their children. The children form a prenatally recruited birth-cohort that will be followed until young adulthood. Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.