Postexertional airway rewarming and thermally induced asthma. New insights into pathophysiology and possible pathogenesis.
Postexertional airway rewarming and thermally induced asthma. New insights into pathophysiology and possible pathogenesis.
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用力后气道复温和热诱发哮喘。
DOI：
10.1172/jci112549
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Strohl,KP
中科院分区：
文献类型：
--
作者：
McFaddenJr,ER;Lenner,KA;Strohl,KP
为了确定运动后的热事件是否在运动性哮喘（EIA）中发挥作用，9名正常人和8名哮喘受试者在三个场合吸入寒冷空气时进行锻炼。在恢复期间，以随机方式给予冷空气、室温和湿度下的空气或身体条件下的空气。在第四次，身体条件的空气是在锻炼。在每次激发之前和之后测量肺力学。在运动过程中吸入身体条件下的空气时，力学没有变化，然而，在恢复过程中增加空气的热含量，在两组中产生了越来越大的阻塞。在一个单独的场合，7名哮喘患者过度呼吸寒冷的空气，要么自发恢复，要么慢慢减少通气。控制通气明显减弱阻塞反应。这些数据表明，EIA的严重程度不仅取决于气道冷却，而且还取决于气道复温的速度和幅度。
To determine if postexercise thermal events play a role in exercise-induced asthma (EIA), nine normal and eight asthmatic subjects on three occasions exercised while they inhaled frigid air. During the recovery period, either cold air, air at room temperature and humidity, or air at body conditions was administered in a random fashion. On a fourth occasion, body-condition air was given during exercise. Pulmonary mechanics were measured before and after each challenge. No changes in mechanics developed when air at body conditions was inhaled during exercise, however, increasing the heat content of the air during recovery produced progressively greater obstruction in both groups. On a separate occasion, seven asthmatics hyperventilated frigid air and either recovered spontaneously or had their ventilation slowly reduced. Controlling ventilation markedly attenuated the obstructive response. These data demonstrate that the severity of EIA is dependent not only on airway cooling but also upon the rapidity and magnitude of airway rewarming postchallenge.