Resolution of Racemates: Did You Say "Classical"?
Resolution of Racemates: Did You Say "Classical"?
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DOI：
10.1002/(sici)1521-3773(19981217)37:23
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发表时间：
1998-12
影响因子：
--
通讯作者：
A. Collet
中科院分区：
文献类型：
--
作者：
A. Collet
一种成功的“族方法”已经在工业上用于大规模对映体拆分。在该方法中，外消旋体通过与三种结构相关的拆分剂的混合物而不是单一的拆分剂形成盐来拆分。虽然这背后的物理化学仍然在很大程度上未被探索，但成功的解决方案更有可能，并且解决效率通常比经典解决方案有所提高。
A successful "family approach" is already being used in industry for large-scale enantiomeric resolutions. In this method, racemates are resolved by formation of salts with mixtures of three structurally related resolving agents instead of a single one. Although the physical chemistry behind this is still largely unexplored, successful resolution is more likely and resolution efficiency is often improved over that of classical resolution.