An epigenetic state associated with areas of gene duplication
An epigenetic state associated with areas of gene duplication
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DOI：
10.1101/gr.5023706
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发表时间：
2006-06-01
期刊：
影响因子：
7
通讯作者：
Chess, Andrew
中科院分区：
文献类型：
--
作者：
Gimelbrant, Alexander A.;Chess, Andrew
异步DNA复制是表观遗传学决定的特征，可见于所有单等位基因表达，包括基因组印记、X失活和常染色体基因的随机单等位基因表达，如免疫球蛋白和嗅觉受体基因。大多数后一类基因是在专注于化学感觉和免疫系统中起作用的基因的实验中确定的。我们对小鼠基因组中的异步复制进行了一项公正的调查，排除了已知的异步复制基因。整整10%(80个被测基因中的8个)表现出了异步复制。新发现的异步复制区的一个共同特征是它们接近串联基因复制区。对其他聚集区的测试支持这样一种观点，即这些区域是由异步复制的基因丰富的。
Asynchronous DNA replication is an epigenetically determined feature found in all cases of monoallelic expression, including genomic imprinting, X-inactivation, and random monoallelic expression of autosomal genes such as immunoglobulins and olfactory receptor genes. Most genes of the latter class were identified in experiments focused on genes functioning in the chemosensory and immune systems. We performed an unbiased survey of asynchronous replication in the mouse genome, excluding known asynchronously replicated genes. Fully 10% (eight of 80) of the genes tested exhibited asynchronous replication. A common feature of the newly identified asynchronously replicated areas is their proximity to areas of tandem gene duplication. Testing of other clustered areas supported the idea that such regions are enriched with asynchronously replicated genes.