METABOLITE TRANSFER VIA ENZYME-ENZYME COMPLEXES
METABOLITE TRANSFER VIA ENZYME-ENZYME COMPLEXES
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DOI：
10.1126/science.3775377
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发表时间：
1986-11-28
期刊：
影响因子：
56.9
通讯作者：
BERNHARD, SA
中科院分区：
文献类型：
--
作者：
SRIVASTAVA, DK;BERNHARD, SA
细胞中酶位点的浓度通常高于同源中间代谢物的浓度。因此，代谢途径或代谢途径的实质部分可以通过酶-酶复合物的形成将代谢物从一个酶位点直接转移到下一个酶位点来进行。这种代谢物转移机制不同于通常假设的代谢物通过水环境的解离和随机扩散负责转移到下一个酶位点。由于直接转移机制不涉及水环境，代谢物相互转化的能量学可能与基于水溶液数据的预期不同。证据总结表明，代谢物的转化和转移，在直接转移途径的平等设施无处不在。
The concentrations of enzyme sites in cells are usually higher than the concentrations of cognate intermediary metabolites. Therefore metabolic pathways or substantial segments of pathways may proceed by the direct transfer of metabolites from one enzyme site to the next by means of enzyme-enzyme complex formation. This mechanism of metabolite transfer differs from that usually assumed where dissociation and random diffusion of metabolite through the aqueous environment is responsible for the transfer to the next enzyme site. Since the direct transfer mechanism does not involve the aqueous environment, the energetics of metabolite interconversion can differ from expectations based on aqueous solution data. Evidence is summarized suggesting that metabolite is transformed and transferred with equal facility everywhere in the direct transfer pathway.