Metabonomics: a platform for studying drug toxicity and gene function
Metabonomics: a platform for studying drug toxicity and gene function
复制标题
DOI：
10.1038/nrd728
复制
发表时间：
2002-02-01
影响因子：
120.1
通讯作者：
Holmes, E
中科院分区：
文献类型：
--
作者：
Nicholson, JK;Connelly, J;Holmes, E
一个分子或分子类别从药物开发管道中丢失的时间越晚，财务成本就越高。因此，最大限度地减少消耗是药物发现计划最重要的目标之一。增加及早做出正确选择的可能性的新技术节省了资源，并提高了安全性、有效性和盈利能力。代谢组学是研究活体代谢谱的一种系统方法，它有望在发现和发展过程的几个阶段提供关于药物毒性、疾病过程和基因功能的信息。
The later that a molecule or molecular class is lost from the drug development pipeline, the higher the financial cost. Minimizing attrition is therefore one of the most important aims of a pharmaceutical discovery programme. Novel technologies that increase the probability of making the right choice early save resources, and promote safety, efficacy and profitability. Metabonomics is a systems approach for studyingin vivometabolic profiles, which promises to provide information on drug toxicity, disease processes and gene function at several stages in the discovery-and-development process.