The D1 dopamine receptor: new perspectives
The D1 dopamine receptor: new perspectives
复制标题
D1 多巴胺受体：新视角
DOI：
10.1016/0165-6147(86)90272-5
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发表时间：
1986
影响因子：
13.8
通讯作者：
J. Saavedra
中科院分区：
文献类型：
--
作者：
J. Kebabian;T. Agui;J. C. Oene;K. Shigematsu;J. Saavedra
几年前，D1受体被认为是“寻求功能的受体”而被忽视，多巴胺能药物的大多数中枢神经系统作用归因于与D2受体的相互作用。然而，最近选择性拮抗剂的开发意味着人们开始重新考虑 D1 受体的作用。 John Kebabian 及其同事概述了这种受体与多巴胺某些生理反应的启动相关的证据。放射性标记的 D1 受体拮抗剂将受体定位在离散的大脑区域，其浓度有时超过 D 2 受体的浓度。在体内，D1 受体选择性激动剂和拮抗剂影响行为。对鱼视网膜的研究提供了明确的证据，表明 D1 受体的刺激可以影响神经元中明确的生理活动。多巴胺受体有两类的假设现已被广泛接受。这两种受体，称为 D1 多巴胺受体和 D2 多巴胺受体，存在于 CNS 以及某些内分泌组织中（参考文献 1；另见插页，TIPS，1985 年 12 月）。现在认为心血管系统中存在的两种多巴胺受体（称为 DA1 和 DA2 多巴胺受体）的药理学实际上分别与 D1 和 D2 受体相同 2-4。对“两种多巴胺受体”假说的普遍接受部分是由于能够区分两类受体的激动剂和拮抗剂的可用性（参见参考文献5）。本综述将仅讨论 D 1 多巴胺受体和卤代苯并氮杂平，这是一类选择性拮抗该受体的化合物（图 1）。 D1受体及其作用的综述
Several years ago, the D1 receptor was dismissed as a" receptor in search of a function" and most CNS effects of dopaminergic drugs were attributed to interactions with the D 2 receptor. More recently, however, the development of selective antagonists has meant that the role of the D1 receptor has begun to be reconsidered. John Kebabian and colleagues outline evidence that this receptor is relevant to the initiation of certain physiological responses to dopamine. Radiolabeled D1 receptor antagonists localize the receptor in discrete brain regions at concentrations sometimes exceeding the concentration of the D 2 receptor. In vivo, D1 receptor selective agonists and antagonists affect behavior. Studies of the fish retina provide unequivocable evidence that stimulation of a D1 receptor can affect well-characterized physiological activity in neurons.The hypothesis that there are two categories of dopamine receptor is now widely accepted. These two receptors, designated as the D1 dopamine receptor and the D2 dopamine receptor, occur in the CNS as well as in certain endocrine tissues (Ref. 1; see also centrefold, TIPS, December 1985). The pharmacology of the two dopamine receptors occurring in the cardiovascular system (designated as the DA1 and DA2 dopamine receptors) is now recognized as being virtually identical to the D1 and D2 receptors, respectively 2-4. This general acceptance of the'two dopamine receptor'hypothesis results, in part, from the availability of agonists and antagonists capable of discriminating between the two categories of receptor (see Ref. 5). This review will address only the D 1 dopamine receptor and the halogenated benzazepines, a class of compounds selectively antagonizing this receptor (Fig. 1). A review of the D1 receptor and its
通过选择性 DA1 拮抗剂 SCH 23390 分离外周多巴胺受体。
DOI：
10.1161/01.hyp.6.2_pt_2.i25
发表时间：
1984
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Goldberg,LI;Glock,D;Kohli,JD;Barnett,A
通讯作者：
Barnett,A
D1/DA1 拮抗剂 SCH 23390 的放射性溴化类似物的正电子断层扫描。
影响因子：
5
作者：
Friedman,AM;DeJesus,OT;Woolverton,WL;vanMoffaert,G;Goldberg,LI;Prasad,A;Barnett,A;Dinerstein,RJ
通讯作者：
Dinerstein,RJ