Impaired neurogenesis in the growth-retarded mouse is reversed by T3 treatment
Impaired neurogenesis in the growth-retarded mouse is reversed by T3 treatment
复制标题
T3 治疗可逆转生长迟缓小鼠中受损的神经发生
作者：
K. Uchida;M. Yonezawa;S. Nakamura;Tetsuya Kobayashi;T. Machida
三碘甲状腺原氨酸（T3）调节神经元发育，T3缺乏会损害儿童中枢神经系统的形成。在这里，我们使用甲状腺功能减退的生长迟缓（grt）小鼠，以调查是否产生新的神经元的T3缺乏的影响。用5-溴-2 ′-脱氧尿苷（BrdU）掺入法测定，grt小鼠海马中的细胞增殖显著降低，而T3处理的grt小鼠中BrdU阳性细胞的数量与野生型小鼠相当。细胞分化率在实验组之间没有差异。这些结果表明，T3在神经发生过程中起着重要作用。
Triiodothyronine (T3) regulates neuronal development, and T3 deficiency impairs the formation of the central nervous system during childhood. Here, we used the hypothyroidal growth-retarded (grt) mouse to investigate whether the generation of new neurons is affected by T3 deficiency. Cell proliferation in the hippocampus, as measured by 5-bromo-2′-deoxyuridine (BrdU) incorporation, was markedly decreased in the grt mouse while the number of BrdU-positive cells in T3-treated grt mice was equivalent to that of wild type mice. The cellular differentiation rate did not differ among the experimental groups. These results suggest that T3 plays an important role during neurogenesis.
发育中的大鼠小脑中甲状腺激素对脑源性神经营养因子基因的启动子特异性调节。
DOI：
10.1210/endo.140.9.6997
发表时间：
1999
期刊：
Endocrinology.
影响因子：
--
作者：
Koibuchi,N;Fukuda,H;Chin,WW
通讯作者：
Chin,WW
DOI：
10.1073/pnas.92.1.210
发表时间：
1995-01-03
影响因子：
11.1
作者：
KIRSCHENBAUM, B;GOLDMAN, SA
通讯作者：
GOLDMAN, SA
大鼠脑神经胶质细胞中甲状腺激素受体亚型的免疫荧光定位。
影响因子：
4.8
作者：
Carlson,DJ;Strait,KA;Schwartz,HL;Oppenheimer,JH
通讯作者：
Oppenheimer,JH