Exposure to iron and welding fumes and the risk of lung cancer
Exposure to iron and welding fumes and the risk of lung cancer
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DOI：
10.5271/sjweh.1296
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发表时间：
2008-12-01
影响因子：
6.3
通讯作者：
Pukkala, Eero
中科院分区：
文献类型：
--
作者：
Siew, Sie Sie;Kauppinen, Timo;Pukkala, Eero
接触铁烟、粉尘和焊接烟雾的情况很普遍，可能会增加患肺癌的风险。这项研究的目的是确定芬兰男性接触铁和焊接烟雾与肺癌发病率之间的关系。方法在1971-1995年期间，通过芬兰癌症登记处（N= 30137）对参加1970年全国人口普查的1906-1945年出生的所有从事经济活动的芬兰男性进行肺癌病例随访。根据可能性、平均水平和估计暴露时间，将他们1970年的人口普查职业转换为对铁和焊接烟雾累积暴露的估计，并使用芬兰工作暴露矩阵。分类累积暴露的相对风险估计值通过泊松回归定义，并根据吸烟、社会经济地位以及暴露于石棉和硅尘进行调整。结果随着铁和焊接烟雾的累积暴露量的增加，肺癌的相对危险度增加。在最高暴露类别中，铁的相对风险为1.35[95%置信区间（95% Cl） 1.05-1.73]，焊接烟雾的相对风险为1.15 （95% CI 0.90-1.46）。肺鳞状细胞癌的相对危险度分别为1.94 （95% CI 1.35-2.78）和1.55 （95% CI 1.08-2.24）。在任何暴露类别中都没有小细胞癌的额外风险。结论职业接触铁和焊接烟雾与肺癌风险增加有关，主要是鳞状细胞癌。同时暴露于这两种物质和其他潜在的与工作有关的致癌物，使对风险因素的独立作用的解释变得复杂。
Objectives Exposure to iron fumes and dust and welding fumes is widespread and may increase the risk of lung cancer. The aim of this study was to identify associations between exposure to iron and welding fumes and the incidence of lung cancer among Finnish men.Methods The cohort of all economically active Finnish men, born in 1906-1945, who participated in the national census in 1970 was followed through the Finnish Cancer Registry for lung cancer cases (N=30 137) during 1971-1995. Their census occupations in 1970 were converted to estimates of cumulative exposure to iron and welding fumes with the Finnish job-exposure matrix on the basis of likelihood, average level, and estimated duration of exposure. Relative risk estimates for categorized cumulative exposure were defined by a Poisson regression, adjusted for smoking, socioeconomic status, and exposure to asbestos and silica dust.Results The relative risks for lung cancer increased as the cumulative exposure to iron and welding fumes increased. The relative risks in the highest exposure category was 1.35 [95% confidence interval (95% Cl) 1.05-1.73] for iron and 1.15 (95% CI 0.90-1.46) for welding fumes. The respective relative risks estimated for squamous-cell carcinoma of the lungs were 1.94 (95% Cl 1.35-2.78) and 1.55 (95% CI 1.08-2.24). There was no excess risk of small-cell carcinoma in any exposure category.Conclusions Occupational exposure to iron and welding fumes was associated with an increase in lung cancer risk, mainly that of squamous-cell carcinoma. The simultaneous exposure to both of these agents and other potential work-related carcinogens complicates the interpretation of the independent roles of the risk factors.