AN EPIDEMIC OF KAWASAKI SYNDROME IN HAWAII
AN EPIDEMIC OF KAWASAKI SYNDROME IN HAWAII
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DOI：
10.1016/s0022-3476(82)80751-8
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发表时间：
1982-01-01
影响因子：
5.1
通讯作者：
PALUMBO, NE
中科院分区：
文献类型：
--
作者：
DEAN, AG;MELISH, ME;PALUMBO, NE
1978年上半年，夏威夷爆发了川崎综合征，这显然是美国第一次全社区爆发。在33例病例中，27例进行了深入的流行病学和微生物学研究。与一般人群相比，川崎综合征患者通常具有日本血统，高收入地位，并且在发病前一个月可能有呼吸道感染史（44%）。金黄色葡萄球菌的检出率不高（15%）；病毒培养、血清学研究、免疫电镜、豚鼠和灵长类动物接种均未发现致病微生物。用皮肤活检标本接种的豚鼠的发热性疾病不能进一步传代。
A community-wide outbreak of Kawasaki syndrome, apparently the 1st in the USA, occurred in Hawaii in the 1st half of 1978. Of the 33 cases, 27 were subjected to intensive epidemiologic and microbiologic study. Patients with Kawasaki syndrome, compared to the general population, more often had Japanese ancestry, high-income status and possibly a history of respiratory infection in the preceding mo. (44%). Staphylococcus aureus was not found in high frequency in the patients (15%); viral cultures, serologic studies, immune-EM and guinea pig and primate inoculation did not reveal a causative microorganism. Febrile illnesses in guinea pigs inoculated with a skin biopsy specimen could not be further passaged.